Quick Search:

uzh logo
Browse by:

Zurich Open Repository and Archive

Maintenance: Tuesday, 5.7.2016, 07:00-08:00

Maintenance work on ZORA and JDB on Tuesday, 5th July, 07h00-08h00. During this time there will be a brief unavailability for about 1 hour. Please be patient.

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-63362

Aguzzi, Adriano; Falsig, Jeppe (2012). Prion propagation, toxicity and degradation. Nature Neuroscience, 15(7):936-939.

[img] PDF - Registered users only
View at publisher


Prion science has been on a rollercoaster for two decades. In the mid 1990s, the specter of mad cow disease (bovine spongiform encephalopathy, BSE) provoked an unprecedented public scare that was first precipitated by the realization that this animal prion disease could be transmitted to humans and then rekindled by the evidence that BSE-infected humans could pass on the infection through blood transfusions. Along with the gradual disappearance of BSE, the interest in prions has waned with the general public, funding agencies and prospective PhD students. In the past few years, however, a bewildering variety of diseases have been found to share features with prion infections, including cell-to-cell transmission. Here we review these developments and summarize those open questions that we currently deem most interesting in prion biology: how do prions damage their hosts, and how do hosts attempt to neutralize invading prions?


40 citations in Web of Science®
43 citations in Scopus®
Google Scholar™



8 downloads since deposited on 02 Jul 2012
2 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Deposited On:02 Jul 2012 15:44
Last Modified:05 Apr 2016 15:53
Publisher:Nature Publishing Group
Publisher DOI:10.1038/nn.3120
PubMed ID:22735515

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page