Quick Search:

uzh logo
Browse by:

Zurich Open Repository and Archive

Maintenance: Tuesday, 5.7.2016, 07:00-08:00

Maintenance work on ZORA and JDB on Tuesday, 5th July, 07h00-08h00. During this time there will be a brief unavailability for about 1 hour. Please be patient.

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-63556

Benke, Dietmar; Zeilhofer, Hanns Ulrich (2012). Divorce of obligatory partners in pain: disruption of GABA(B) receptor heterodimers in neuralgia. EMBO Journal, 31(15):3234-3236.

[img]Published Version
PDF - Registered users only
View at publisher


It is now well established that G protein-coupled receptors can exist not only as homodimers, but also as heterodimers or higher order oligomers. However, whether and how dimerization of the receptors is regulated is poorly understood. In this issue of The EMBO Journal, the team of Marc Landry provides evidence for an intriguing mechanism by which—under pathological conditions—GABAB receptor heterodimers at the cell surface are disrupted and thereby inactivated. An impressive set of experiments thus reveals a novel mechanism regulating the number of functional GABAB receptors in the plasma membrane and shows that the receptor heterodimer may not be as stable as we previously thought.




2 downloads since deposited on 19 Jul 2012
0 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, not refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Date:26 June 2012
Deposited On:19 Jul 2012 09:11
Last Modified:05 Apr 2016 15:53
Publisher:Nature Publishing Group
Publisher DOI:10.1038/emboj.2012.174
PubMed ID:22735189

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page