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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-63556

Benke, Dietmar; Zeilhofer, Hanns Ulrich (2012). Divorce of obligatory partners in pain: disruption of GABA(B) receptor heterodimers in neuralgia. EMBO Journal, 31(15):3234-3236.

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Abstract

It is now well established that G protein-coupled receptors can exist not only as homodimers, but also as heterodimers or higher order oligomers. However, whether and how dimerization of the receptors is regulated is poorly understood. In this issue of The EMBO Journal, the team of Marc Landry provides evidence for an intriguing mechanism by which—under pathological conditions—GABAB receptor heterodimers at the cell surface are disrupted and thereby inactivated. An impressive set of experiments thus reveals a novel mechanism regulating the number of functional GABAB receptors in the plasma membrane and shows that the receptor heterodimer may not be as stable as we previously thought.

Item Type:Journal Article, not refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:26 June 2012
Deposited On:19 Jul 2012 09:11
Last Modified:22 Dec 2013 20:08
Publisher:Nature Publishing Group
ISSN:0261-4189
Publisher DOI:10.1038/emboj.2012.174
PubMed ID:22735189
Citations:Web of Science®
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