UZH-Logo

Maintenance Infos

Divorce of obligatory partners in pain: disruption of GABA(B) receptor heterodimers in neuralgia


Benke, Dietmar; Zeilhofer, Hanns Ulrich (2012). Divorce of obligatory partners in pain: disruption of GABA(B) receptor heterodimers in neuralgia. EMBO Journal, 31(15):3234-3236.

Abstract

It is now well established that G protein-coupled receptors can exist not only as homodimers, but also as heterodimers or higher order oligomers. However, whether and how dimerization of the receptors is regulated is poorly understood. In this issue of The EMBO Journal, the team of Marc Landry provides evidence for an intriguing mechanism by which—under pathological conditions—GABAB receptor heterodimers at the cell surface are disrupted and thereby inactivated. An impressive set of experiments thus reveals a novel mechanism regulating the number of functional GABAB receptors in the plasma membrane and shows that the receptor heterodimer may not be as stable as we previously thought.

It is now well established that G protein-coupled receptors can exist not only as homodimers, but also as heterodimers or higher order oligomers. However, whether and how dimerization of the receptors is regulated is poorly understood. In this issue of The EMBO Journal, the team of Marc Landry provides evidence for an intriguing mechanism by which—under pathological conditions—GABAB receptor heterodimers at the cell surface are disrupted and thereby inactivated. An impressive set of experiments thus reveals a novel mechanism regulating the number of functional GABAB receptors in the plasma membrane and shows that the receptor heterodimer may not be as stable as we previously thought.

Altmetrics

Downloads

2 downloads since deposited on 19 Jul 2012
0 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, not refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:26 June 2012
Deposited On:19 Jul 2012 09:11
Last Modified:05 Apr 2016 15:53
Publisher:Nature Publishing Group
ISSN:0261-4189
Publisher DOI:10.1038/emboj.2012.174
PubMed ID:22735189
Permanent URL: http://doi.org/10.5167/uzh-63556

Download

[img]
Content: Published Version
Filetype: PDF - Registered users only
Size: 271kB
View at publisher

TrendTerms

TrendTerms displays relevant terms of the abstract of this publication and related documents on a map. The terms and their relations were extracted from ZORA using word statistics. Their timelines are taken from ZORA as well. The bubble size of a term is proportional to the number of documents where the term occurs. Red, orange, yellow and green colors are used for terms that occur in the current document; red indicates high interlinkedness of a term with other terms, orange, yellow and green decreasing interlinkedness. Blue is used for terms that have a relation with the terms in this document, but occur in other documents.
You can navigate and zoom the map. Mouse-hovering a term displays its timeline, clicking it yields the associated documents.

Author Collaborations