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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-63941

Bostanci, Nagihan; Belibasakis, Georgios N (2012). Porphyromonas gingivalis: an invasive and evasive opportunistic oral pathogen. FEMS Microbiology Letters, 333(1):1-9.

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Abstract

Porphyromonas gingivalis is a Gram-negative oral anaerobe that is involved in the pathogenesis of periodontitis, an inflammatory disease that destroys the tissues supporting the tooth, eventually leading to tooth loss. Porphyromonas gingivalis has can locally invade periodontal tissues and evade the host defence mechanisms. In doing so, it utilizes a panel of virulence factors that cause deregulation of the innate immune and inflammatory responses. The present review discusses the invasive and evasive strategies of P. gingivalis and the role of its major virulence factors in these, namely lipopolysaccharide, capsule, gingipains and fimbriae. Moreover, the role of P. gingivalis as a 'keystone' biofilm species in orchestrating a host response, is highlighted.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Center for Dental Medicine > Institute of Oral Biology
DDC:610 Medicine & health
Language:English
Date:2012
Deposited On:31 Jul 2012 11:54
Last Modified:09 Dec 2013 05:55
Publisher:Wiley-Blackwell
ISSN:0378-1097
Publisher DOI:10.1111/j.1574-6968.2012.02579.x
PubMed ID:22530835
Citations:Web of Science®. Times Cited: 36
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Scopus®. Citation Count: 40

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