UZH-Logo

Maintenance Infos

Nonsteroidal antiinflammatory drugs, acetaminophen, and hypertension


Sudano, I; Flammer, A J; Roas, S; Enseleit, F; Noll, G; Ruschitzka, F (2012). Nonsteroidal antiinflammatory drugs, acetaminophen, and hypertension. Current Hypertension Reports, 14(4):304-309.

Abstract

Selective and non-selective non-steroidal anti-inflammatory drugs (NSAIDs) as well as acetaminophen belong to the most widely prescribed therapeutic agents worldwide. Their efficacy in pain relief notwithstanding, the use of NSAIDs is associated with an increased cardiovascular risk, which can be partly attributed to their blood pressure raising potential. Adequately powered placebo-controlled trials specifically evaluating the cardiovascular safety of NSAIDs vs. selective COX inhibitors are currently underway. This review summarizes the current knowledge on the cardiovascular effects of NSAIDs and acetaminophen, and their potential clinical consequences.

Selective and non-selective non-steroidal anti-inflammatory drugs (NSAIDs) as well as acetaminophen belong to the most widely prescribed therapeutic agents worldwide. Their efficacy in pain relief notwithstanding, the use of NSAIDs is associated with an increased cardiovascular risk, which can be partly attributed to their blood pressure raising potential. Adequately powered placebo-controlled trials specifically evaluating the cardiovascular safety of NSAIDs vs. selective COX inhibitors are currently underway. This review summarizes the current knowledge on the cardiovascular effects of NSAIDs and acetaminophen, and their potential clinical consequences.

Citations

15 citations in Web of Science®
17 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

202 downloads since deposited on 31 Jul 2012
58 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Cardiology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2012
Deposited On:31 Jul 2012 15:12
Last Modified:05 Apr 2016 15:55
Publisher:Springer
ISSN:1522-6417
Additional Information:The original publication is available at www.springerlink.com
Publisher DOI:10.1007/s11906-012-0274-7
PubMed ID:22610476
Permanent URL: http://doi.org/10.5167/uzh-63964

Download

[img]
Preview
Content: Accepted Version
Filetype: PDF
Size: 185kB
View at publisher

TrendTerms

TrendTerms displays relevant terms of the abstract of this publication and related documents on a map. The terms and their relations were extracted from ZORA using word statistics. Their timelines are taken from ZORA as well. The bubble size of a term is proportional to the number of documents where the term occurs. Red, orange, yellow and green colors are used for terms that occur in the current document; red indicates high interlinkedness of a term with other terms, orange, yellow and green decreasing interlinkedness. Blue is used for terms that have a relation with the terms in this document, but occur in other documents.
You can navigate and zoom the map. Mouse-hovering a term displays its timeline, clicking it yields the associated documents.

Author Collaborations