Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-64004
Dresch, C; Leverrier, Yann; Marvel, Jacqueline; Shortman, Ken (2012). Development of antigen cross-presentation capacity in dendritic cells. Trends in Immunology, 33(8):381-388.
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Cross-presentation by dendritic cells (DCs) of exogenous antigens on MHC class I is important for the generation of immune responses to intracellular pathogens, as well as for maintenance of self tolerance. In mice, the CD8(+) DC lineage is specialised for this role. However, DCs of this lineage are not born with cross-presentation capacity. Several studies have demonstrated that it must be induced as a later developmental step by cytokines such as granulocyte macrophage colony-stimulating factor (GM-CSF), or by microbial products such as toll-like receptor (TLR) ligands. Increased cross-presentation capacity is thus induced in peripheral CD8 lineage DCs during inflammation or infection. However, this capacity is already fully developed in steady-state thymic CD8(+) DCs, in accordance with their role in the deletion of self-reactive developing T cells.
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|Item Type:||Journal Article, refereed, further contribution|
|Communities & Collections:||05 Vetsuisse Faculty > Institute of Virology|
|DDC:||570 Life sciences; biology|
|Deposited On:||07 Aug 2012 12:28|
|Last Modified:||11 Dec 2013 23:53|
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