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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-64332

Wolf, Monika Julia; Hoos, Alexandra; Bauer, Judith; Boettcher, Steffen; Knust, Markus; Weber, Achim; Simonavicius, Nicole; Schneider, Christoph; Lang, Matthias; Stürzl, Michael; Croner, Roland S; Konrad, Andreas; Manz, Markus G; Moch, Holger; Aguzzi, Adriano; van Loo, Geert; Pasparakis, Manolis; Prinz, Marco; Borsig, Lubor; Heikenwalder, Mathias (2012). Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway. Cancer Cell, 22(1):91-105.

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Increased expression of the chemokine CCL2 in tumor cells correlates with enhanced metastasis, poor prognosis, and recruitment of CCR2(+)Ly6C(hi) monocytes. However, the mechanisms driving tumor cell extravasation through the endothelium remain elusive. Here, we describe CCL2 upregulation in metastatic UICC stage IV colon carcinomas and demonstrate that tumor cell-derived CCL2 activates the CCR2(+) endothelium to increase vascular permeability in vivo. CCR2 deficiency prevents colon carcinoma extravasation and metastasis. Of note, CCR2 expression on radio-resistant cells or endothelial CCR2 expression restores extravasation and metastasis in Ccr2(-/-) mice. Reduction of CCR2 expression on myeloid cells decreases but does not prevent metastasis. CCL2-induced vascular permeability and metastasis is dependent on JAK2-Stat5 and p38MAPK signaling. Our study identifies potential targets for treating CCL2-dependent metastasis.


77 citations in Web of Science®
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Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Hematology
04 Faculty of Medicine > University Hospital Zurich > Institute of Surgical Pathology
04 Faculty of Medicine > Institute of Physiology
07 Faculty of Science > Institute of Physiology

04 Faculty of Medicine > Center for Integrative Human Physiology
04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Deposited On:23 Aug 2012 12:15
Last Modified:05 Apr 2016 15:56
Publisher DOI:10.1016/j.ccr.2012.05.023
PubMed ID:22789541

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