Quick Search:

uzh logo
Browse by:

Zurich Open Repository and Archive

Maintenance: Tuesday, 5.7.2016, 07:00-08:00

Maintenance work on ZORA and JDB on Tuesday, 5th July, 07h00-08h00. During this time there will be a brief unavailability for about 1 hour. Please be patient.

Wilson, Nicole H; Stoeckli, Esther T (2012). Sonic Hedgehog regulates Wnt activity during neural circuit formation. Vitamins and Hormones, 88:173-209.

Full text not available from this repository.

View at publisher


Gradients of secreted morphogens, such as Sonic hedgehog (Shh), Wnt, and TGFβ/Bmp, have classically been shown to control many aspects of early development by regulating cell proliferation and determining cell fate. However, recent studies demonstrate that these molecules also play important and evolutionarily conserved roles in later aspects of neural development. Depending on the context, these molecules can elicit gene transcription in the nucleus, or alternatively can provide instructive signals at the growth cone that induce local and rapid changes in cytoskeletal organization. Shh can activate different cellular transduction pathways via its binding to alternative coreceptor complexes or simply by adaptation of its "classical" signaling pathway. However, in most of its activities during neural development, Shh does not act alone but rather in concert with other morphogens, particularly the Wnts. This review provides an overview of the mechanisms by which Shh signaling acts in concert with Wnts to mediate a myriad of cellular processes that are required for neural circuit formation.


9 citations in Web of Science®
9 citations in Scopus®
Google Scholar™


Additional indexing

Item Type:Journal Article, not refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
Dewey Decimal Classification:570 Life sciences; biology
Uncontrolled Keywords:axon guidance, morphogens, neural circuit formation, commissural neurons, neuronal polarization, spinal cord patterning
Deposited On:06 Sep 2012 08:48
Last Modified:05 Apr 2016 15:56
Publisher DOI:10.1016/B978-0-12-394622-5.00008-0
PubMed ID:22391304

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page