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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-64434

Robinson, Mark D; Strbenac, Dario; Stirzaker, Clare; Statham, Aaron L; Song, Jenny Z; Speed, Terence P; Clark, Susan J (2012). Copy-number-aware differential analysis of quantitative DNA sequencing data. Genome Research, 22(12):2489-2496.

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Abstract

Developments in microarray and high throughput sequencing (HTS) technologies have resulted in a rapid expansion of research into epigenomic changes that occur in normal development and in the progression of disease, such as cancer. Not surprisingly, copy number variation (CNV) has a direct effect on HTS read densities and can therefore bias differential detection results. We have developed a flexible approach called ABCD-DNA (Affinity Based Copy-number-aware Differential quantitative DNA sequencing analyses) that integrates CNV and other systematic factors directly into the differential enrichment engine.

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
DDC:570 Life sciences; biology
Uncontrolled Keywords:Statistics; Epigenomics; Next generation sequencing
Language:English
Date:9 August 2012
Deposited On:06 Sep 2012 09:16
Last Modified:27 Nov 2013 20:19
Publisher:Cold Spring Harbor Laboratory Press
ISSN:1088-9051
Publisher DOI:10.1101/gr.139055.112
PubMed ID:22879430
Citations:Web of Science®. Times Cited: 7
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