Quick Search:

uzh logo
Browse by:

Zurich Open Repository and Archive

Maintenance: Tuesday, 5.7.2016, 07:00-08:00

Maintenance work on ZORA and JDB on Tuesday, 5th July, 07h00-08h00. During this time there will be a brief unavailability for about 1 hour. Please be patient.

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-64434

Robinson, Mark D; Strbenac, Dario; Stirzaker, Clare; Statham, Aaron L; Song, Jenny Z; Speed, Terence P; Clark, Susan J (2012). Copy-number-aware differential analysis of quantitative DNA sequencing data. Genome Research, 22(12):2489-2496.

Accepted Version
View at publisher


Developments in microarray and high throughput sequencing (HTS) technologies have resulted in a rapid expansion of research into epigenomic changes that occur in normal development and in the progression of disease, such as cancer. Not surprisingly, copy number variation (CNV) has a direct effect on HTS read densities and can therefore bias differential detection results. We have developed a flexible approach called ABCD-DNA (Affinity Based Copy-number-aware Differential quantitative DNA sequencing analyses) that integrates CNV and other systematic factors directly into the differential enrichment engine.




27 downloads since deposited on 06 Sep 2012
5 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
Dewey Decimal Classification:570 Life sciences; biology
Uncontrolled Keywords:Statistics; Epigenomics; Next generation sequencing
Date:9 August 2012
Deposited On:06 Sep 2012 09:16
Last Modified:05 Apr 2016 15:56
Publisher:Cold Spring Harbor Laboratory Press
Publisher DOI:10.1101/gr.139055.112
PubMed ID:22879430

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page