Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-64526
Thunnissen, Erik; Bubendorf, Lukas; Dietel, Manfred; Elmberger, Göran; Kerr, Keith; Lopez-Rios, Fernando; Moch, Holger; Olszewski, Wlodzimierz; Pauwels, Patrick; Penault-Llorca, Frédérique; Rossi, Giulio (2012). EML4-ALK testing in non-small cell carcinomas of the lung: a review with recommendations. Virchows Archiv, 461(3):245-257.
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In non-small cell lung cancer, epidermal growth factor receptor gene mutations and anaplastic lymphoma kinase (ALK) gene rearrangements have a major impact upon the level of response to treatment with specific tyrosine kinase inhibitors. This review describes the molecular basis of ALK inhibition, summarizes current data on the effectiveness and safety of ALK inhibition therapy, describes the different testing methodologies with their advantages and disadvantages, provides a suggested testing algorithm and puts forward a proposal for an external quality assessment program in ALK testing.
|Item Type:||Journal Article, refereed, further contribution|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Institute of Surgical Pathology|
|DDC:||610 Medicine & health|
|Deposited On:||03 Sep 2012 16:07|
|Last Modified:||09 Dec 2013 01:16|
|Free access at:||Publisher DOI. An embargo period may apply.|
|Citations:||Web of Science®. Times Cited: 21|
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