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EML4-ALK testing in non-small cell carcinomas of the lung: a review with recommendations


Thunnissen, Erik; Bubendorf, Lukas; Dietel, Manfred; Elmberger, Göran; Kerr, Keith; Lopez-Rios, Fernando; Moch, Holger; Olszewski, Wlodzimierz; Pauwels, Patrick; Penault-Llorca, Frédérique; Rossi, Giulio (2012). EML4-ALK testing in non-small cell carcinomas of the lung: a review with recommendations. Virchows Archiv, 461(3):245-257.

Abstract

In non-small cell lung cancer, epidermal growth factor receptor gene mutations and anaplastic lymphoma kinase (ALK) gene rearrangements have a major impact upon the level of response to treatment with specific tyrosine kinase inhibitors. This review describes the molecular basis of ALK inhibition, summarizes current data on the effectiveness and safety of ALK inhibition therapy, describes the different testing methodologies with their advantages and disadvantages, provides a suggested testing algorithm and puts forward a proposal for an external quality assessment program in ALK testing.

In non-small cell lung cancer, epidermal growth factor receptor gene mutations and anaplastic lymphoma kinase (ALK) gene rearrangements have a major impact upon the level of response to treatment with specific tyrosine kinase inhibitors. This review describes the molecular basis of ALK inhibition, summarizes current data on the effectiveness and safety of ALK inhibition therapy, describes the different testing methodologies with their advantages and disadvantages, provides a suggested testing algorithm and puts forward a proposal for an external quality assessment program in ALK testing.

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85 citations in Web of Science®
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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Surgical Pathology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2012
Deposited On:03 Sep 2012 14:07
Last Modified:05 Apr 2016 15:57
Publisher:Springer
ISSN:0945-6317
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:10.1007/s00428-012-1281-4
PubMed ID:22825000
Permanent URL: http://doi.org/10.5167/uzh-64526

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