Guggenberger, Roman; Morsbach, Fabian; Alkadhi, Hatem; Vich, Magdalena; Pfammatter, Thomas; Hodler, Juerg; Andreisek, Gustav (2013). C-arm flat-panel CT arthrography of the wrist and elbow: first experiences in human cadavers. Skeletal Radiology, 42(3):419-429.
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OBJECTIVE: To determine the optimal intra-articular iodine concentration for C-arm flat-panel computed tomography (FPCT) arthrography using advanced joint phantoms and to evaluate its application in human cadaveric wrists and elbows. Multi-detector (MD) CT served as the standard of reference. MATERIALS AND METHODS: Joint phantoms and 10 human cadaveric wrist and elbow joints were scanned with C-arm FPCT (5-s, 8-s, and 20-s runs) and standard MDCT using different and optimal concentrations of iodinated contrast material. CT numbers of contrast material, tissue, and noise were measured and contrast-to-noise ratios (CNR) calculated for quantitative analysis. Image and depiction of cartilage, bone, and soft tissues were rated. Radiation doses were compared. RESULTS: In FPCT, iodine concentrations positively correlated with CT numbers and noise of contrast material and with radiation dose (r = 0.713-0.996, p < 0.05 each). At an iodine concentration of 45 mg/ml, CNR of cartilage and soft tissues were highest for all FPCT acquisitions and higher than in MDCT. The 20-s FPCT run performed best for image quality and depiction of anatomical structures and was rated overall equal to MDCT (p = 0.857). CONCLUSION: The optimal iodine concentration for C-arm FPCT arthrography in this study is 45 mg/ml, leading to superior CNR and image quality for an optimal FPCT protocol compared with standard MDCT arthrography in human cadaveric joints.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > Institute of Anatomy|
04 Faculty of Medicine > University Hospital Zurich > Clinic for Diagnostic and Interventional Radiology
|DDC:||570 Life sciences; biology|
610 Medicine & health
|Deposited On:||04 Sep 2012 14:48|
|Last Modified:||27 Feb 2013 16:18|
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