UZH-Logo

Maintenance Infos

Blue-yellow colour vision impairment and cognitive deficits in occasional and dependent stimulant users


Hulka, Lea M; Wagner, Michael; Preller, Katrin H; Jenni, Daniela; Quednow, Boris (2013). Blue-yellow colour vision impairment and cognitive deficits in occasional and dependent stimulant users. International Journal of Neuropsychopharmacology, 16(03):535-547.

Abstract

Specific blue-yellow color vision impairment has been reported in cocaine-dependent users and it was postulated that drug-induced changes in retinal dopamine neurotransmission are responsible. However, it is unclear whether these changes are confined to chronic cocaine users, whether they are specific for dopaminergic stimulants such as cocaine and amphetamine, and whether they are related to cognitive functions such as working memory, encoding, and consolidation. In 47 occasional and 29 dependent cocaine users, 23 MDMA users, and 47 stimulant-naïve controls, color vision discrimination was measured with the Lanthony Desaturated Panel D-15 Test and memory performance with the Auditory Verbal Learning Test. Both occasional and dependent cocaine users showed higher Color Confusion Indices than controls. Users of the serotonergic stimulant MDMA (26%), occasional (30%) and dependent cocaine users (34%) exhibited more frequent blue-yellow color vision disorders compared to controls (9%). Inferior performance of MDMA users was caused by a subgroup with high amphetamine co-use (55%), while MDMA use alone was not associated with decreased blue-yellow discrimination (0%). Cognitive performance was worse in cocaine users with color vision disorder compared to users and controls with intact color vision and both color vision impairment and cognitive deficits were related to cocaine use. Already occasional cocaine and amphetamine use might induce blue-yellow color vision impairment, whereas the serotonergic stimulant MDMA does not impair color vision. The association between color vision impairment and cognitive deficits in cocaine users may reflect that retinal and cerebral dopamine alterations are linked to a certain degree.

Specific blue-yellow color vision impairment has been reported in cocaine-dependent users and it was postulated that drug-induced changes in retinal dopamine neurotransmission are responsible. However, it is unclear whether these changes are confined to chronic cocaine users, whether they are specific for dopaminergic stimulants such as cocaine and amphetamine, and whether they are related to cognitive functions such as working memory, encoding, and consolidation. In 47 occasional and 29 dependent cocaine users, 23 MDMA users, and 47 stimulant-naïve controls, color vision discrimination was measured with the Lanthony Desaturated Panel D-15 Test and memory performance with the Auditory Verbal Learning Test. Both occasional and dependent cocaine users showed higher Color Confusion Indices than controls. Users of the serotonergic stimulant MDMA (26%), occasional (30%) and dependent cocaine users (34%) exhibited more frequent blue-yellow color vision disorders compared to controls (9%). Inferior performance of MDMA users was caused by a subgroup with high amphetamine co-use (55%), while MDMA use alone was not associated with decreased blue-yellow discrimination (0%). Cognitive performance was worse in cocaine users with color vision disorder compared to users and controls with intact color vision and both color vision impairment and cognitive deficits were related to cocaine use. Already occasional cocaine and amphetamine use might induce blue-yellow color vision impairment, whereas the serotonergic stimulant MDMA does not impair color vision. The association between color vision impairment and cognitive deficits in cocaine users may reflect that retinal and cerebral dopamine alterations are linked to a certain degree.

Citations

9 citations in Web of Science®
9 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

136 downloads since deposited on 04 Sep 2012
0 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Clinic for Psychiatry, Psychotherapy, and Psychosomatics
04 Faculty of Medicine > Neuroscience Center Zurich
08 University Research Priority Programs > Integrative Human Physiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2013
Deposited On:04 Sep 2012 13:38
Last Modified:05 Apr 2016 15:57
Publisher:Cambridge University Press
ISSN:1461-1457
Funders:Schweizerischer Nationalfonds
Additional Information:Copyright: Cambridge University Press
Publisher DOI:10.1017/S1461145712000624
PubMed ID:22704223
Permanent URL: http://doi.org/10.5167/uzh-64537

Download

[img]
Preview
Filetype: PDF
Size: 154kB
View at publisher

TrendTerms

TrendTerms displays relevant terms of the abstract of this publication and related documents on a map. The terms and their relations were extracted from ZORA using word statistics. Their timelines are taken from ZORA as well. The bubble size of a term is proportional to the number of documents where the term occurs. Red, orange, yellow and green colors are used for terms that occur in the current document; red indicates high interlinkedness of a term with other terms, orange, yellow and green decreasing interlinkedness. Blue is used for terms that have a relation with the terms in this document, but occur in other documents.
You can navigate and zoom the map. Mouse-hovering a term displays its timeline, clicking it yields the associated documents.

Author Collaborations