Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive 

Baur, Volker; Hänggi, Jürgen; Langer, Nicolas; Jäncke, Lutz (2013). Resting-State Functional and Structural Connectivity Within an Insula-Amygdala Route Specifically Index State and Trait Anxiety. Biological Psychiatry, 73(1):85-92.

Full text not available from this repository.

Abstract

BACKGROUND: Conjoint activity of the insula and amygdala has frequently been reported during emotional stimulation in general and in anxiety-related contexts in particular. However, direct connectivity between the insula and amygdala in this framework has received little attention so far. Studying whether inter-individual differences in anxiety reflect variation in insula-amygdala connectivity is a way to push forward the understanding of network-related aspects underlying anxious behavior. METHODS: To investigate functional and structural connectivity, we applied resting-state functional magnetic resonance imaging and diffusion tensor imaging in a group of 32 healthy subjects. Specific measures of connectivity between subregions of the insula and amygdala were related to subjects' anxiety levels. RESULTS: Resting-state functional connectivity between the anterior insula and the basolateral amygdala was strongly related to state anxiety, explaining 40% of behavioral variance across subjects. This was substantiated by applying tractography, yielding a relationship between trait anxiety and axial diffusivity for a direct pathway between anterior insula and basolateral amygdala. CONCLUSIONS: Our results indicate that anterior insula and basolateral amygdala constitute a network part that is prominently linked to anxiety. Within this route, state and trait behavioral impacts seem to be specifically linked to dynamic functional and more static structural neural aspects, respectively. Insula-amygdala resting-state functional connectivity can be assessed in an easy and straightforward way and has high potential to serve as a biomarker for anxiety.

Item Type:Journal Article, refereed, original work
Communities & Collections:06 Faculty of Arts > Institute of Psychology
DDC:150 Psychology
Language:English
Date:2013
Deposited On:10 Oct 2012 09:01
Last Modified:28 Nov 2013 02:13
Publisher:Elsevier
ISSN:0006-3223
Publisher DOI:10.1016/j.biopsych.2012.06.003
PubMed ID:22770651
Citations:Web of Science®. Times Cited: 10
Google Scholar™
Scopus®. Citation Count: 12

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page