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Sustained cognitive impairments after clinical recovery of severe depression


Boeker, H; Schulze, J; Richter, A; Nikisch, G; Schuepbach, D; Grimm, S (2012). Sustained cognitive impairments after clinical recovery of severe depression. Journal of Nervous and Mental Disease, 200(9):773-776.

Abstract

Neuropsychological impairment is prominent in patients with depression, but it is unclear whether deficits persist after clinical response. This study aimed to investigate neuropsychological functions in the course of the illness. Depressive patients were investigated in the acute state and after clinical response using an extensive neuropsychological test battery. After clinical response, there was only a partial improvement in learning and memory and there were no changes regarding working memory, executive functions, and attention. Transient impairments in visual learning and memory suggest a depression-related state effect. The continuing deficits in attention, working memory, and executive function might be considered a trait marker.

Neuropsychological impairment is prominent in patients with depression, but it is unclear whether deficits persist after clinical response. This study aimed to investigate neuropsychological functions in the course of the illness. Depressive patients were investigated in the acute state and after clinical response using an extensive neuropsychological test battery. After clinical response, there was only a partial improvement in learning and memory and there were no changes regarding working memory, executive functions, and attention. Transient impairments in visual learning and memory suggest a depression-related state effect. The continuing deficits in attention, working memory, and executive function might be considered a trait marker.

Citations

12 citations in Web of Science®
11 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Clinic for Psychiatry, Psychotherapy, and Psychosomatics
04 Faculty of Medicine > University Hospital Zurich > Clinic for Psychiatry and Psychotherapy
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:September 2012
Deposited On:12 Sep 2012 09:24
Last Modified:05 Apr 2016 15:57
Publisher:Lippincott Wiliams & Wilkins
ISSN:0022-3018
Publisher DOI:https://doi.org/10.1097/NMD.0b013e318266ba14
PubMed ID:22922242

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