Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-64599
Traber, G L; Chen, C C; Huang, Y Y; Spoor, M; Roos, J; Frens, M A; Straumann, D; Grimm, C (2012). Albino mice as an animal model for infantile nystagmus syndrome. Investigative Ophthalmology and Visual Science, 53(9):5737-5747.
|PDF - Registered users only|
Purpose. Individuals with oculocutaneous albinism are predisposed to visual system abnormalities affecting the retina and retinofugal projections, which may lead to reduced visual acuity and Infantile Nystagmus Syndrome (INS). Due to absence of an established mammalian animal model, mechanisms underlying INS remain elusive. In this study, we screened wild-type mice of varying pigmentation for ocular motor abnormalities in order to identify a possible mouse model for INS. Methods. Three albino mouse strains (CD1, BALB/c, DBA/1), and two normally pigmented strains (129S6, C57BL/6) were screened using infrared oculography. Varying visual stimuli (black or white background, stationary pattern, optokinetic, i.e., horizontally rotating pattern) were displayed to the full (fVF) or anterior visual field (aVF) of the restrained mouse. Results. We found spontaneous nystagmus, specifically jerks and oscillations, in albino mice under all experimental conditions. Median eye velocity was between 0.8 and 3.4 deg/s, depending on the strain. In contrast, the eyes in pigmented mice were nearly stable with a median absolute eye velocity of below 0.4 deg/s. In albino mice, fVF optokinetic stimuli elicited an optokinetic response (OKR) in the correct direction, albeit with superimposed oscillations. However, aVF optokinetic stimuli evoked reversed OKR in these strains, a well known feature of INS. Conclusions. Based on our results, we endorse the investigated albino mouse strains as new animal models for INS.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Ophthalmology Clinic|
04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology
07 Faculty of Science > Institute of Molecular Life Sciences
08 University Research Priority Programs > Integrative Human Physiology
|DDC:||570 Life sciences; biology|
610 Medicine & health
|Deposited On:||11 Sep 2012 14:19|
|Last Modified:||25 Nov 2012 21:50|
|Publisher:||Association for Research in Vision and Ophthalmology|
Users (please log in): suggest update or correction for this item
Repository Staff Only: item control page