Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-64605
Zobi, Fabio; Blacque, Olivier; Jacobs, Robert A; Schaub, Marcus C; Bogdanova, Anna Yu (2012). 17 e- rhenium dicarbonyl CO-releasing molecules on a cobalamin scaffold for biological application. Dalton Transactions, 41(2):370-378.
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Cyanocobalamin (B(12)) offers a biocompatible scaffold for CO-releasing 17-electron dicarbonyl complexes based on the cis-trans-[Re(II)(CO)(2)Br(2)](0) core. A Co-C≡N-Re conjugate is produced in a short time and high yield from the reaction of [Et(4)N](2)[Re(II)Br(4)(CO)(2)] (ReCORM-1) with B(12). The B(12)-Re(II)(CO)(2) derivatives show a number of features which make them pharmaceutically acceptable CO-releasing molecules (CORMs). These cobalamin conjugates are characterized by an improved stability in aqueous aerobic media over the metal complex alone, and afford effective therapeutic protection against ischemia-reperfusion injury in cultured cardiomyocytes. The non-toxicity (at μM concentrations) of the resulting metal fragment after CO release is attributed to the oxidation of the metal and formation in solution of the ReO(4)(-) anion, which is among the least toxic of all of the rare inorganic compounds. Theoretical and experimental studies aimed at elucidating the aqueous chemistry of ReCORM-1 are also described.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > Institute of Pharmacology and Toxicology|
05 Vetsuisse Faculty > Institute of Veterinary Physiology
07 Faculty of Science > Institute of Inorganic Chemistry
|DDC:||570 Life sciences; biology|
610 Medicine & health
|Deposited On:||12 Sep 2012 15:19|
|Last Modified:||05 Dec 2013 19:03|
|Publisher:||Royal Society of Chemistry|
|Citations:||Web of Science®. Times cited: 10|
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