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Antiangiogenic treatment for multiple CNS hemangioblastomas


Riklin, C; Seystahl, K; Hofer, S; Happold, C; Winterhalder, R; Weller, M (2012). Antiangiogenic treatment for multiple CNS hemangioblastomas. Onkologie, 35(7-8):443-445.

Abstract

Background: Hemangioblastomas represent rare benign tumors of the central nervous system. In the case of metastatic spread and limited surgical options, systemic treatment may be considered. However there is no standard of care beyond surgery. Case Report: We report the cases of 2 patients with progressive multilocular hemangioblastomas, who showed clinical benefit and radiological stabilization of tumor growth after treatment with bevacizumab, an antibody against the vascular endothelial growth factor. Conclusion: Our case reports suggest activity of bevacizumab in hemangioblastomas after failure of standard therapeutic options.

Background: Hemangioblastomas represent rare benign tumors of the central nervous system. In the case of metastatic spread and limited surgical options, systemic treatment may be considered. However there is no standard of care beyond surgery. Case Report: We report the cases of 2 patients with progressive multilocular hemangioblastomas, who showed clinical benefit and radiological stabilization of tumor growth after treatment with bevacizumab, an antibody against the vascular endothelial growth factor. Conclusion: Our case reports suggest activity of bevacizumab in hemangioblastomas after failure of standard therapeutic options.

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4 citations in Web of Science®
4 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology
04 Faculty of Medicine > University Hospital Zurich > Clinic for Oncology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2012
Deposited On:08 Oct 2012 13:27
Last Modified:16 Jul 2016 07:06
Publisher:Karger
ISSN:0378-584X
Additional Information:© 2012 S. Karger AG
Publisher DOI:10.1159/000341075
PubMed ID:22846977
Permanent URL: http://doi.org/10.5167/uzh-64667

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