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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-64716

Vorburger, M S; Broglie, M A; Soltermann, Al; Haerle, S K; Haile, S R; Huber, G F; Stoeckli, S J (2012). Validity of frozen section in sentinel lymph node biopsy for the staging in oral and oropharyngeal squamous cell carcinoma. Journal of Surgical Oncology, 106(7):816-819.

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BACKGROUND AND OBJECTIVES: The potential of avoiding a secondary surgery for therapeutic neck dissection (TND) by sentinel node (SN) positivity makes the intraoperative evaluation of SNs an attractive option. The aim of this study was to analyze accuracy of intraoperative frozen section (FS) for detection of occult metastases in a large single institutional patient cohort undergoing SN-biopsy. METHODS: Between 2000 and 2010, 92 consecutive patients with early stage oropharyngeal squamous cell carcinoma (OSCC) (cT1/cT2/cN0) were prospectively enrolled. Detection rate of occult metastases by monoslice FS was compared with the definitive histopathologic work up by step serial sectioning (SSS) and immunohistochemistry (IHC). In case of SN-positivity on FS TND was performed in the same narcosis. RESULTS: 15/92 patients revealed positive SNs by FS compared to 34/92 after SSS and IHC. Sensitivity, NPV and FNR for the detection of all sizes of metastases by FS was 47, 77, and 52%, for isolated tumor cells (ITC) 8, 86, 92%, for micrometastases 43, 90, 57%, and for macrometastases 93, 98, 7%. CONCLUSION: Sensitivity of FS by the monoslice depends on the metastases size and allows a single-stage procedure in half of the SN-positive patients. To improve sensitivity for small tumor deposits either a multislice-technique or molecular methods are needed. J. Surg. Oncol © 2012 Wiley Periodicals, Inc.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Otorhinolaryngology
04 Faculty of Medicine > University Hospital Zurich > Institute of Surgical Pathology
04 Faculty of Medicine > Epidemology, Biostatistics and Prevention Institute (EBPI)
DDC:610 Medicine & health
Deposited On:18 Sep 2012 13:19
Last Modified:02 Dec 2013 07:49
Free access at:Official URL. An embargo period may apply.
Publisher DOI:10.1002/jso.23156
Official URL:http://onlinelibrary.wiley.com/doi/10.1002/jso.23156/pdf
PubMed ID:22585742
Citations:Web of Science®. Times Cited: 2
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Scopus®. Citation Count: 2

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