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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-64889

Tissot van Patot, Martha C; Ebensperger, German; Gassmann, Max; Llanos, Aníbal J (2012). The hypoxic placenta. High Altitude Medicine and Biology, 13(3):176-184.

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Abstract

Hypoxia of the placenta is integral to complications of pregnancy, including preeclampsia, intrauterine growth restriction, and small-for-gestational age babies. Hypoxia in the placenta is associated with vascular remodeling, hypertension, metabolic changes, oxidative stress, mitochondrial dysfunction, and endoplasmic reticular stress. Hypoxia induces similar outcomes in other organs such as the lungs, kidney, and gut. Comparing and contrasting the effects of hypoxia on placental functions and functions of lung, kidney, and gut can lead to novel hypotheses and investigations, furthering our understanding of the impact of hypoxia on these diverse yet similar organs. In this review, we compare and contrast hypoxic placental responses to those in the other organ and cell systems.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Center for Integrative Human Physiology
05 Vetsuisse Faculty > Institute of Veterinary Physiology
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2012
Deposited On:01 Oct 2012 14:27
Last Modified:02 Dec 2013 11:22
Publisher:Mary Ann Liebert
ISSN:1527-0297
Additional Information:This is a copy of an article published in the High Altitude Medicine and Biology © 2012 [copyright Mary Ann Liebert, Inc.]; High Altitude Medicine and Biology is available online at: http://www.liebertonline.com.
Publisher DOI:10.1089/ham.2012.1046
PubMed ID:22994517
Citations:Web of Science®. Times Cited: 2
Google Scholar™
Scopus®. Citation Count: 2

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