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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-6520

Zhou, K; Asherson, P; Sham, P; Franke, B; Anney, R J L; Buitelaar, J; Ebstein, R; Gill, M; Brookes, K; Buschgens, C; Campbell, D; Chen, W; Christiansen, H; Fliers, E; Gabriëls, I; Johansson, L; Marco, R; Mulas, F; Müller, U; Mulligan, A; Neale, B M; Rijsdijk, F; Rommelse, N; Uebel, H; Psychogiou, L; Xu, X; Banaschewski, T; Sonuga-Barke, E; Eisenberg, J; Manor, I; Miranda, A; Oades, R D; Roeyers, H; Rothenberger, A; Sergeant, J; Steinhausen, H C; Taylor, E; Thompson, M; Faraone, S V (2008). Linkage to chromosome 1p36 for attention-deficit/hyperactivity disorder traits in school and home settings. Biological Psychiatry, 64(7):571-576.

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BACKGROUND: Limited success has been achieved through previous attention-deficit/hyperactivity disorder (ADHD) linkage scans, which were all designed to map genes underlying the dichotomous phenotype. The International Multi-centre ADHD Genetics (IMAGE) project performed a whole genome linkage scan specifically designed to map ADHD quantitative trait loci (QTL). METHODS: A set of 1094 single selected Caucasian ADHD nuclear families was genotyped on a highly accurate and informative single nucleotide polymorphism (SNP) panel. Two quantitative traits measuring the children's symptoms in home and school settings were collected and standardized according to a population sample of 8000 children to reflect the developmental nature and gender prevalence difference of ADHD. Univariate linkage test was performed on both traits and their mean score. RESULTS: A significant common linkage locus was found at chromosome 1p36 with a locus-specific heritability of 5.1% and a genomewide empirical p < .04. Setting-specific suggestive linkage signals were also found: logarithm of odds (LOD) = 2.2 at 9p23 for home trait and LOD = 2.6 at 11q21 for school trait. CONCLUSIONS: These results indicate that given large samples with proper phenotypic measures, searching for ADHD genes with a QTL strategy is an important alternative to using the clinical diagnosis. The fact that our linkage region 1p36 overlaps with the dyslexia QTL DYX8 further suggests it is potentially a pleiotropic locus for ADHD and dyslexia.


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Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Center for Child and Adolescent Psychiatry
Dewey Decimal Classification:610 Medicine & health
Date:1 October 2008
Deposited On:09 Jan 2009 10:03
Last Modified:05 Apr 2016 12:37
Publisher DOI:10.1016/j.biopsych.2008.02.024
PubMed ID:18439570

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