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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-6532

Mulligan, A; Anney, R J; O'Regan, M; Chen, W; Butler, L; Fitzgerald, M; Buitelaar, J; Steinhausen, H C; Rothenberger, A; Minderaa, R; Nijmeijer, J; Hoekstra, P J; Oades, R D; Roeyers, H; Buschgens, C; Christiansen, H; Franke, B; Gabriels, I; Hartman, C; Kuntsi, J; Marco, R; Meidad, S; Mueller, U; Psychogiou, L; Rommelse, N; Thompson, M; Uebel, H; Banaschewski, T; Ebstein, R; Eisenberg, J; Manor, I; Miranda, A; Mulas, F; Sergeant, J; Sonuga-Barke, E; Asherson, P; Faraone, S V; Gill, M (2009). Autism symptoms in attention-deficit/hyperactivity disorder: a familial trait which correlates with conduct, oppositional defiant, language and motor disorders. Journal of Autism and Developmental Disorders, 39(2):197-209.

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It is hypothesised that autism symptoms are present in Attention-Deficit/Hyperactivity Disorder (ADHD), are familial and index subtypes of ADHD. Autism symptoms were compared in 821 ADHD probands, 1050 siblings and 149 controls. Shared familiality of autism symptoms and ADHD was calculated using DeFries-Fulker analysis. Autism symptoms were higher in probands than siblings or controls, and higher in male siblings than male controls. Autism symptoms were familial, partly shared with familiality of ADHD in males. Latent class analysis using SCQ-score yielded five classes; Class 1(31%) had few autism symptoms and low comorbidity; Classes 2-4 were intermediate; Class 5(7%) had high autism symptoms and comorbidity. Thus autism symptoms in ADHD represent a familial trait associated with increased neurodevelopmental and oppositional/conduct disorders.


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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Center for Child and Adolescent Psychiatry
Dewey Decimal Classification:610 Medicine & health
Date:February 2009
Deposited On:05 Jan 2009 08:45
Last Modified:05 Apr 2016 12:37
Publisher DOI:10.1007/s10803-008-0621-3
PubMed ID:18642069

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