# Post-Protein-Binding Reactivity and Modifications of the fac-Re(CO)(3)](+) Core

Zobi, Fabio; Spingler, Bernhard (2012). Post-Protein-Binding Reactivity and Modifications of the fac-Re(CO)(3)](+) Core. Inorganic Chemistry, 51(3):1210-1212.

## Abstract

The reactivity of the Re(CO)(3)(H2O)(2)](+) complex coordinated to the His15 residue of HEW lysozyme is described. In the fully metalated protein (Lys-1), the Re ion retains its reactivity only toward selected ligands, while others induce a ligand-mediated demetalation of the enzyme. It is further shown that some of the complexes that may be engineered'' on the lysozyme do not react with the free protein even if present in solution in excess. The formation of stable metal adducts starting from Lys-1 was confirmed by X-ray crystallography.

## Abstract

The reactivity of the Re(CO)(3)(H2O)(2)](+) complex coordinated to the His15 residue of HEW lysozyme is described. In the fully metalated protein (Lys-1), the Re ion retains its reactivity only toward selected ligands, while others induce a ligand-mediated demetalation of the enzyme. It is further shown that some of the complexes that may be engineered'' on the lysozyme do not react with the free protein even if present in solution in excess. The formation of stable metal adducts starting from Lys-1 was confirmed by X-ray crystallography.

## Citations

7 citations in Web of Science®
5 citations in Scopus®

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Item Type: Journal Article, refereed, original work 07 Faculty of Science > Department of Chemistry 540 Chemistry English February 2012 17 Oct 2012 12:36 05 Apr 2016 15:59 American Chemical Society 0020-1669 This document is the Accepted Manuscript version of a Published Work that appeared in final form in Inorganic Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. https://doi.org/10.1021/ic2023314 ISI:000300474700004

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