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Assessment of cortisol response with low-dose and high-dose ACTH in patients with chronic fatigue snydrome and healthy comparison subjects


Gaab, Jens; Hüster, D; Peisen, R; Engert, V; Heitz, Vera; Schad, Tanja; Schürmeyer, Thomas H; Ehlert, Ulrike (2003). Assessment of cortisol response with low-dose and high-dose ACTH in patients with chronic fatigue snydrome and healthy comparison subjects. Psychosomatics, 44:113-119.

Abstract

A reduced secretion of cortisol has been proposed as a possible explanation of the symptoms in chronic fatigue syndrome. However, the evidence of hypocortisolism in chronic fatigue syndrome is conflicting. In order to simultaneously assess possible alterations in adrenocortical sensitivity and secretory adrenal reserve, the authors administered both low-dose and high-dose ACTH to a group of 18 chronic fatigue syndrome patients and 18 age- and gender-matched healthy comparison subjects. No response differences for salivary and plasma cortisol were detectable after administration of either low-dose or high-dose ACTH, indicating that primary adrenal insufficiency is unlikely to play a significant role in the etiology of chronic fatigue syndrome.

A reduced secretion of cortisol has been proposed as a possible explanation of the symptoms in chronic fatigue syndrome. However, the evidence of hypocortisolism in chronic fatigue syndrome is conflicting. In order to simultaneously assess possible alterations in adrenocortical sensitivity and secretory adrenal reserve, the authors administered both low-dose and high-dose ACTH to a group of 18 chronic fatigue syndrome patients and 18 age- and gender-matched healthy comparison subjects. No response differences for salivary and plasma cortisol were detectable after administration of either low-dose or high-dose ACTH, indicating that primary adrenal insufficiency is unlikely to play a significant role in the etiology of chronic fatigue syndrome.

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18 citations in Web of Science®
23 citations in Scopus®
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Additional indexing

Item Type:Journal Article, not refereed, original work
Communities & Collections:06 Faculty of Arts > Institute of Psychology
Dewey Decimal Classification:150 Psychology
Language:English
Date:2003
Deposited On:22 Oct 2012 09:12
Last Modified:05 Apr 2016 16:00
Publisher:American Psychiatric Press Inc
ISSN:0033-3182
Publisher DOI:https://doi.org/10.1176/appi.psy.44.2.113
PubMed ID:12618533

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