Quick Search:

uzh logo
Browse by:

Zurich Open Repository and Archive

Maintenance: Tuesday, July the 26th 2016, 07:00-10:00

ZORA's new graphical user interface will be relaunched (For further infos watch out slideshow ZORA: Neues Look & Feel). There will be short interrupts on ZORA Service between 07:00am and 10:00 am. Please be patient.

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-65562

Farooqui, Sarfarazhussain; Pellegrino, Mark W; Rimann, Ivo; Morf, Matthias K; Müller, Louisa; Fröhli, Erika; Hajnal, Alex (2012). Coordinated Lumen Contraction and Expansion during Vulval Tube Morphogenesis in Caenorhabditis elegans. Developmental Cell, 23(3):494-506.

PDF - Registered users only
View at publisher


Morphogenesis is a developmental phase during which cell fates are executed. Mechanical forces shaping individual cells play a key role during tissue morphogenesis. By investigating morphogenesis of the Caenorhabditis elegans hermaphrodite vulva, we show that the force-generating actomyosin network is differentially regulated by NOTCH and EGFR/RAS/MAPK signaling to shape the vulval tube. NOTCH signaling activates expression of the RHO kinase LET-502 in the secondary cell lineage through the ETS-family transcription factor LIN-1. LET-502 induces actomyosin-mediated contraction of the apical lumen in the secondary toroids, thereby generating a dorsal pushing force. In contrast, MAPK signaling in the primary lineage downregulates LET-502 RHO kinase expression to prevent toroid contraction and allow the gonadal anchor cell to expand the dorsal lumen of the primary toroids. The antagonistic action of the MAPK and NOTCH pathways thus controls vulval tube morphogenesis linking cell fate specification to morphogenesis.


10 citations in Web of Science®
10 citations in Scopus®
Google Scholar™



0 downloads since deposited on 23 Oct 2012
0 downloads since 12 months

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
Dewey Decimal Classification:570 Life sciences; biology
Date:11 September 2012
Deposited On:23 Oct 2012 15:46
Last Modified:05 Apr 2016 16:00
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:10.1016/j.devcel.2012.06.019
PubMed ID:22975323

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page