Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-6559
Zhou, K; Chen, W; Buitelaar, J; Banaschewski, T; Oades, R D; Franke, B; Sonuga-Barke, E; Ebstein, R; Eisenberg, J; Gill, M; Manor, I; Miranda, A; Mulas, F; Roeyers, H; Rothenberger, A; Sergeant, J; Steinhausen, H C; Lasky-Su, J; Taylor, E; Brookes, K J; Xu, X; Neale, B M; Rijsdijk, F; Thompson, M; Asherson, P; Faraone, S V (2008). Genetic heterogeneity in ADHD: DAT1 gene only affects probands without CD. American Journal of Medical Genetics. Part B, 147B(8):1481-1487.
Previous studies have found heterogeneous association between DAT1-3'-UTR-VNTR and attention deficit hyperactivity disorder (ADHD). Various proportions of conduct disorder (CD) comorbidity in their ADHD samples may partially explain the observational discrepancies. Evidence for this comes from family and twin studies which found ADHD probands with CD (ADHD + CD) are genetically different from those without CD (ADHD - CD). Genotypes of 20 DAT1 markers were analyzed in 576 trios, consisting of 141 ADHD + CD and 435 ADHD - CD. In addition to the classical TDT test, a specific genetic heterogeneity test was performed to identify variants that have different transmission patterns in the two phenotypic subgroups. After multiple-test correction, rs40184 and rs2652511 were significant in TDT tests. Further heterogeneity test found the two SNPs had a significant transmission pattern difference between ADHD + CD and ADHD - CD children, indicating that DAT1 has a significantly greater genetic influence on ADHD without CD. Although the result needs further replications, it does highlight the importance of selecting genetically homogeneous samples for molecular genetic analyses of ADHD. (c) 2007 Wiley-Liss, Inc.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > Center for Child and Adolescent Psychiatry|
|DDC:||610 Medicine & health|
|Date:||05 December 2008|
|Deposited On:||12 Dec 2008 12:00|
|Last Modified:||28 Nov 2013 00:04|
|Citations:||Web of Science®. Times cited: 20|
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