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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-656

Dickson, B J; van der Straten, A; Dominguez, M; Hafen, E (1996). Mutations modulating Raf signaling in Drosophila eye development. Genetics, 142(1):163-171.



The R7 fate is specified during Drosophila eye development by an inductive signal transduced intracellularly via the Raf kinase. We have performed a genetic screen for dominant mutations that alter the efficiency with which cells respond to a constitutively activated Raf kinase. Such mutations may affect genes involved in signal transduction downstream of Raf. We have isolated 44 mutations that define eight genes. One of these encodes a mitogen-activated protein kinase homologue: another is a putative target gene of this signaling pathway. We present the results of this screen in detail, as well as a preliminary genetic analysis of the six loci still to be characterized molecularly.


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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Zoology (former)
Dewey Decimal Classification:570 Life sciences; biology
590 Animals (Zoology)
Date:1 January 1996
Deposited On:11 Feb 2008 12:17
Last Modified:05 Apr 2016 12:15
Publisher:Genetics Society of America
Related URLs:http://www.genetics.org/cgi/content/abstract/142/1/163
PubMed ID:8770593

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