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Inverse finite element characterization of the human myometrium derived from uniaxial compression experiments


Weiss, S; Niederer, P; Navarini, A; Caduff, R; Bajka, M (2008). Inverse finite element characterization of the human myometrium derived from uniaxial compression experiments. Biomedizinische Technik. Biomedical Engineering, 53(2):52-58.

Abstract

The low strain-rate behavior of the human myometrium under compression was determined. To this end, uniaxial, unconstrained compression experiments were conducted on a total of 25 samples from three excised human uteri at strain rates between 0.001 s(-1) and 0.008 s(-1). A three-dimensional finite element model of each sample was created and used together with an optimization algorithm to find material parameters in an inverse estimation process. Friction and shape irregularities of samples were incorporated in the models. The uterine specimens in compression were modeled as viscoelastic, non-linear, nearly incompressible and isotropic continua. Simulations of uniaxial, frictionless compressions of an idealized cuboid were used to compare the resulting material parameters among each other. The intra- and inter-subject variability in stiffness of specimens was found to be large and to cover such a wide range that the effect of anisotropy which is of minor influence under compressive deformations in the first place could be neglected. Material parameters for a viscoelastic model based on a decoupled, reduced quadratic strain-energy function were presented for the uterine samples representing a median stiffness.

The low strain-rate behavior of the human myometrium under compression was determined. To this end, uniaxial, unconstrained compression experiments were conducted on a total of 25 samples from three excised human uteri at strain rates between 0.001 s(-1) and 0.008 s(-1). A three-dimensional finite element model of each sample was created and used together with an optimization algorithm to find material parameters in an inverse estimation process. Friction and shape irregularities of samples were incorporated in the models. The uterine specimens in compression were modeled as viscoelastic, non-linear, nearly incompressible and isotropic continua. Simulations of uniaxial, frictionless compressions of an idealized cuboid were used to compare the resulting material parameters among each other. The intra- and inter-subject variability in stiffness of specimens was found to be large and to cover such a wide range that the effect of anisotropy which is of minor influence under compressive deformations in the first place could be neglected. Material parameters for a viscoelastic model based on a decoupled, reduced quadratic strain-energy function were presented for the uterine samples representing a median stiffness.

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Additional indexing

Other titles:Von einaxialen Druckversuchen hergeleitete inverse Finite-Elemente-Charakterisierung des menschlichen Myometriums
Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Gynecology
04 Faculty of Medicine > Institute of Biomedical Engineering
04 Faculty of Medicine > University Hospital Zurich > Institute of Surgical Pathology
Dewey Decimal Classification:170 Ethics
610 Medicine & health
Language:English
Date:2008
Deposited On:11 Dec 2008 09:21
Last Modified:05 Apr 2016 12:37
Publisher:De Gruyter
ISSN:0013-5585
Publisher DOI:10.1515/BMT.2008.006
PubMed ID:18605921
Permanent URL: http://doi.org/10.5167/uzh-6562

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