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Comparison of cardiopulmonary effects of dexmedetomidine administered as a constant rate infusion without loading dose in sheep and goats anaesthetised with sevoflurane


Kästner, Sabine Beate Rita; Boller, J; Kutter, Annette P N; Pakarinen, S M; Ramela, M P; Huhtinen, M K (2007). Comparison of cardiopulmonary effects of dexmedetomidine administered as a constant rate infusion without loading dose in sheep and goats anaesthetised with sevoflurane. Small Ruminant Research, 71(1-3):75-82.

Abstract

The purpose of this study was to compare the cardiopulmonary effects of dexmedetomidine in anaesthetised sheep and goats. The initial vasopressor effects were prevented by using a constant rate infusion (CRI), without a loading dose.
In six sevoflurane anaesthetised goats and sheep dexmedetomidine was infused as CRI (2 μg/kg/h). Before, during and for 30 min after the infusion, cardiac output (CO), systemic and pulmonary arterial pressures, heart rate (HR), respiratory mechanics, inspired and expired gas concentrations, arterial and mixed venous blood gases and the plasma concentration of dexmedetomidine were measured.
In goats, CO, HR and mean arterial pressure decreased below baseline values by 20, 40 and 20%, respectively. Systemic vascular resistance (SVR) only decreased after the infusion. Gas exchange and respiratory mechanics remained unchanged. In sheep, CO did not change and SVR decreased progressively up to 45% below baseline. Changes in gas exchange and respiratory mechanics were mild but highly variable. The plasma concentrations of dexmedetomidine were similar in sheep and goats.
In conclusion, goats seem to be more sensitive to centrally mediated cardiovascular effects of dexmedetomidine than sheep, which is not related to dexmedetomidine disposition. Adverse pulmonary effects were completely prevented by CRI without loading dose in goats but not in sheep.

The purpose of this study was to compare the cardiopulmonary effects of dexmedetomidine in anaesthetised sheep and goats. The initial vasopressor effects were prevented by using a constant rate infusion (CRI), without a loading dose.
In six sevoflurane anaesthetised goats and sheep dexmedetomidine was infused as CRI (2 μg/kg/h). Before, during and for 30 min after the infusion, cardiac output (CO), systemic and pulmonary arterial pressures, heart rate (HR), respiratory mechanics, inspired and expired gas concentrations, arterial and mixed venous blood gases and the plasma concentration of dexmedetomidine were measured.
In goats, CO, HR and mean arterial pressure decreased below baseline values by 20, 40 and 20%, respectively. Systemic vascular resistance (SVR) only decreased after the infusion. Gas exchange and respiratory mechanics remained unchanged. In sheep, CO did not change and SVR decreased progressively up to 45% below baseline. Changes in gas exchange and respiratory mechanics were mild but highly variable. The plasma concentrations of dexmedetomidine were similar in sheep and goats.
In conclusion, goats seem to be more sensitive to centrally mediated cardiovascular effects of dexmedetomidine than sheep, which is not related to dexmedetomidine disposition. Adverse pulmonary effects were completely prevented by CRI without loading dose in goats but not in sheep.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Veterinary Clinic > Equine Department
Dewey Decimal Classification:570 Life sciences; biology
630 Agriculture
Uncontrolled Keywords:Sheep, Goat, Dexmedetomidine, Sevoflurane
Date:2007
Deposited On:12 Nov 2012 10:57
Last Modified:03 May 2016 17:59
Publisher:Elsevier
ISSN:0921-4488
Publisher DOI:https://doi.org/10.1016/j.smallrumres.2006.05.001
Permanent URL: https://doi.org/10.5167/uzh-66439

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