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Integration with the human genome of peptide sequences obtained by high-throughput mass spectrometry.


Desiere, F; Deutsch, E W; Nesvizhskii, A I; Mallick, P; King, N L; Eng, J K; Aderem, A; Boyle, R; Brunner, E; Donohoe, S; Fausto, N; Hafen, E; Hood, L; Katze, M G; Kennedy, K A; Kregenow, F; Lee, H; Lin, B; Martin, D; Ranish, J A; Rawlings, D J; Samelson, L E; Shiio, Y; Watts, J D; Wollscheid, B; Wright, M E; Yan, W; Yang, L; Yi, E C; Zhang, H; Aebersold, R (2005). Integration with the human genome of peptide sequences obtained by high-throughput mass spectrometry. Genome Biology, 6(1):R9.

Abstract

A crucial aim upon the completion of the human genome is the verification and functional annotation of all predicted genes and their protein products. Here we describe the mapping of peptides derived from accurate interpretations of protein tandem mass spectrometry (MS) data to eukaryotic genomes and the generation of an expandable resource for integration of data from many diverse proteomics experiments. Furthermore, we demonstrate that peptide identifications obtained from high-throughput proteomics can be integrated on a large scale with the human genome. This resource could serve as an expandable repository for MS-derived proteome information.

A crucial aim upon the completion of the human genome is the verification and functional annotation of all predicted genes and their protein products. Here we describe the mapping of peptides derived from accurate interpretations of protein tandem mass spectrometry (MS) data to eukaryotic genomes and the generation of an expandable resource for integration of data from many diverse proteomics experiments. Furthermore, we demonstrate that peptide identifications obtained from high-throughput proteomics can be integrated on a large scale with the human genome. This resource could serve as an expandable repository for MS-derived proteome information.

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175 citations in Web of Science®
191 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Zoology (former)
Dewey Decimal Classification:570 Life sciences; biology
590 Animals (Zoology)
Language:English
Date:2005
Deposited On:11 Feb 2008 12:17
Last Modified:05 Apr 2016 12:15
Publisher:BioMed Central
ISSN:1465-6906
Publisher DOI:10.1186/gb-2004-6-1-r9
PubMed ID:15642101
Permanent URL: http://doi.org/10.5167/uzh-665

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