Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-6720
Ohlerth, Stefanie; Dennler, Mathias; Rüefli, E; Hauser, Beat; Poirier, V; Siebeck, N; Roos, Malgorzata; Kaser-Hotz, Barbara (2008). Contrast harmonic imaging characterization of canine splenic lesions. Journal of Veterinary Internal Medicine, 22(5):1095-1102.
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BACKGROUND: Although B-mode ultrasound is very sensitive for the detection of splenic lesions, its specificity is low. Contrast harmonic imaging is used successfully to differentiate benign from malignant liver lesions in humans and dogs. HYPOTHESIS: Contrast harmonic imaging could be useful to differentiate benign and malignant splenic lesions in dogs. ANIMALS: Sixty dogs (clinical patients) with splenic abnormalities detected during abdominal ultrasonography. METHODS: A prospective study was performed with a Philips ATL 5000 unit for contrast pulse inversion harmonic imaging (mechanical index: 0.08, contrast medium: SonoVue). Perfusion was assessed subjectively and quantitatively. RESULTS: Cytology or histology identified 27 benign (hyperplasia, extramedullary hematopoiesis, hematoma) and 29 malignant (hemangiosarcoma, malignant lymphoma, malignant histiocytosis, mesenchymal tumors without classification, mast cell tumors, and others) lesions and 4 normal spleens. Except for 1 benign nodule, extensive to moderate hypoechogenicity was only seen in malignant lesions during wash-in, at peak enhancement, and during wash-out (P= .0001, odds ratios: 37.9 [95% CI 4.5-316.5], 66.4 [95% CI 8.0-551.1], and 36.9 [95% CI 4.4-308.4]). Although all but 1 benign lesion enhanced well and were mildly hypo-, iso-, or hyperechoic in comparison with the normal spleen during all blood pool phases, marked enhancement occurred both in benign as well as in malignant splenic lesions. Quantitative perfusion values did not differ significantly between benign and malignant lesions. CONCLUSIONS AND CLINICAL IMPORTANCE: Moderate to extensive hypoechogenicity clearly identifies canine splenic malignant lesions. In nodules with marked enhancement, contrast harmonic ultrasound is of limited value and histology is needed.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > Institute of Social and Preventive Medicine|
05 Vetsuisse Faculty > Veterinary Clinic > Department of Small Animals > Division of Diagnostic Imaging
05 Vetsuisse Faculty > Institute of Veterinary Pathology
|DDC:||570 Life sciences; biology|
610 Medicine & health
|Date:||04 August 2008|
|Deposited On:||10 Dec 2008 14:47|
|Last Modified:||27 Nov 2013 19:42|
|Citations:||Web of Science®. Times cited: 19|
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