UZH-Logo

Maintenance Infos

Novel Pathogenetic Mechanisms in Pulmonary Hypertension


Ulrich Somaini, Silvia. Novel Pathogenetic Mechanisms in Pulmonary Hypertension. 2009, University of Zurich, Faculty of Medicine.

Abstract

My research interest is the pathogenetic mechanisms underlying various forms of pulmonary hypertension (PH). We described that arterial and chronic thromboembolic PH share pathogenetic mechanisms by showing comparable acute vasoreactivity. Based on these findings we successfully introduced vasodilator therapy in many patients with chronic thromboembolic PH. We found that patients with idiopathic PH have increased regulatory and decreased cytotoxic T cells in their blood and that their B lymphocytes express a different RNA pattern compared with healthy controls. Our results support a pathogenetic role of the immune system in PH. We demonstrated that sleep related breathing disorders, osteoporosis and hyperparathyroidism are common in PH and found that genetic polymorphism of the serotonin transporter are associated with PH in COPD. Some of these findings may have important implication for the management and treatment of PH-patients.

My research interest is the pathogenetic mechanisms underlying various forms of pulmonary hypertension (PH). We described that arterial and chronic thromboembolic PH share pathogenetic mechanisms by showing comparable acute vasoreactivity. Based on these findings we successfully introduced vasodilator therapy in many patients with chronic thromboembolic PH. We found that patients with idiopathic PH have increased regulatory and decreased cytotoxic T cells in their blood and that their B lymphocytes express a different RNA pattern compared with healthy controls. Our results support a pathogenetic role of the immune system in PH. We demonstrated that sleep related breathing disorders, osteoporosis and hyperparathyroidism are common in PH and found that genetic polymorphism of the serotonin transporter are associated with PH in COPD. Some of these findings may have important implication for the management and treatment of PH-patients.

Downloads

2 downloads since deposited on 03 Dec 2012
0 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Habilitation
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic and Policlinic for Internal Medicine
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2009
Deposited On:03 Dec 2012 13:31
Last Modified:05 Apr 2016 16:08
Number of Pages:64
Permanent URL: https://doi.org/10.5167/uzh-67690

Download

[img]
Language: English
Filetype: PDF - Registered users only
Size: 2MB

TrendTerms

TrendTerms displays relevant terms of the abstract of this publication and related documents on a map. The terms and their relations were extracted from ZORA using word statistics. Their timelines are taken from ZORA as well. The bubble size of a term is proportional to the number of documents where the term occurs. Red, orange, yellow and green colors are used for terms that occur in the current document; red indicates high interlinkedness of a term with other terms, orange, yellow and green decreasing interlinkedness. Blue is used for terms that have a relation with the terms in this document, but occur in other documents.
You can navigate and zoom the map. Mouse-hovering a term displays its timeline, clicking it yields the associated documents.

Author Collaborations