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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-6827

Hart, J; Ackermann, M; Jayawardane, G; Russell, G; Haig, D M; Reid, H; Stewart, J P (2007). Complete sequence and analysis of the ovine herpesvirus 2 genome. Journal of General Virology, 88(Pt 1):28-39.

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Ovine herpesvirus 2 (OvHV-2) is endemic in sheep populations worldwide and causes malignant
catarrhal fever (MCF), a lymphoproliferative disease, in cattle, bison and deer. OvHV-2 has been
placed in the gammaherpesvirus subfamily and is related closely to Alcelaphine herpesvirus 1
(AlHV-1). Here, the cloning, sequencing and analysis of the complete OvHV-2 genome derived
from a lymphoblastoid cell line from an affected cow (BJ1035) are reported. The unique portion of
the genome consists of 130 930 bp, with a mean G+C content of 52 mol%. The unique DNA is
flanked by multiple copies of terminal repeat elements 4205 bp in length, with a mean G+C content of 72 mol%. Analysis revealed 73 open reading frames (ORFs), the majority (62) of which showed homology to other gammaherpesvirus genes. A further subset of nine ORFs is shared with only the related AlHV-1. Three ORFs are entirely unique to OvHV-2, including a spliced homologue of cellular interleukin-10 that retains the exon structure of the cellular gene. The sequence of
OvHV-2 is a critical first step in the study of the pathogenesis and treatment of MCF.


49 citations in Web of Science®
48 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Virology
Dewey Decimal Classification:570 Life sciences; biology
Deposited On:23 Mar 2009 15:21
Last Modified:05 Apr 2016 12:38
Publisher:Society for General Microbiology
Publisher DOI:10.1099/vir.0.82284-0
PubMed ID:17170433

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