Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-6827
Hart, J; Ackermann, M; Jayawardane, G; Russell, G; Haig, D M; Reid, H; Stewart, J P (2007). Complete sequence and analysis of the ovine herpesvirus 2 genome. Journal of General Virology, 88(Pt 1):28-39.
View at publisher
Ovine herpesvirus 2 (OvHV-2) is endemic in sheep populations worldwide and causes malignant catarrhal fever (MCF), a lymphoproliferative disease, in cattle, bison and deer. OvHV-2 has been placed in the gammaherpesvirus subfamily and is related closely to Alcelaphine herpesvirus 1 (AlHV-1). Here, the cloning, sequencing and analysis of the complete OvHV-2 genome derived from a lymphoblastoid cell line from an affected cow (BJ1035) are reported. The unique portion of the genome consists of 130 930 bp, with a mean G+C content of 52 mol%. The unique DNA is flanked by multiple copies of terminal repeat elements 4205 bp in length, with a mean G+C content of 72 mol%. Analysis revealed 73 open reading frames (ORFs), the majority (62) of which showed homology to other gammaherpesvirus genes. A further subset of nine ORFs is shared with only the related AlHV-1. Three ORFs are entirely unique to OvHV-2, including a spliced homologue of cellular interleukin-10 that retains the exon structure of the cellular gene. The sequence of OvHV-2 is a critical first step in the study of the pathogenesis and treatment of MCF.
105 downloads since deposited on 23 Mar 2009
38 downloads since 12 months
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||05 Vetsuisse Faculty > Institute of Virology|
|Dewey Decimal Classification:||570 Life sciences; biology|
|Deposited On:||23 Mar 2009 15:21|
|Last Modified:||28 Nov 2013 00:05|
|Publisher:||Society for General Microbiology|
Users (please log in): suggest update or correction for this item
Repository Staff Only: item control page