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Small organometallic compounds as antibacterial agents


Patra, Malay; Gasser, Gilles; Metzler-Nolte, Nils (2012). Small organometallic compounds as antibacterial agents. Dalton Transactions, 41:6350-6358.

Abstract

The emergence of bacterial resistance to commercial antibiotics is an issue of global importance. During the last two decades, the number of antibacterial agents that have been discovered and introduced into the market has steadily declined and failed to meet the challenges posed by rapidly increasing resistance of the pathogens against common antibacterial drugs. The development of new classes of compounds to control the virulence of the pathogens is therefore urgently required. This perspective describes the historical development in brief and recent advances on the preparation of small organometallic compounds as new classes of antibacterial agents with potential for clinical development.

Abstract

The emergence of bacterial resistance to commercial antibiotics is an issue of global importance. During the last two decades, the number of antibacterial agents that have been discovered and introduced into the market has steadily declined and failed to meet the challenges posed by rapidly increasing resistance of the pathogens against common antibacterial drugs. The development of new classes of compounds to control the virulence of the pathogens is therefore urgently required. This perspective describes the historical development in brief and recent advances on the preparation of small organometallic compounds as new classes of antibacterial agents with potential for clinical development.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Language:English
Date:March 2012
Deposited On:14 Jan 2013 11:44
Last Modified:05 Apr 2016 16:14
Publisher:Royal Society of Chemistry (RSC)
ISSN:1477-9226
Publisher DOI:https://doi.org/10.1039/c2dt12460b
PubMed ID:22411216

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