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Evaluation of HIV protease inhibitor use and the risk of sudden death or nonhemorrhagic stroke


Worm, S W; Kamara, D A; Reiss, P; Fontas, E; De Wit, S; El-Sadr, W; D'Arminio Monforte, A; Law, M; Phillips, A; Ryom, L; Dabis, F; Weber, R; Sabin, C; Lundgren, J D (2012). Evaluation of HIV protease inhibitor use and the risk of sudden death or nonhemorrhagic stroke. Journal of Infectious Diseases, 205(4):535-539.

Abstract

Concerns have arisen about possible effects of protease inhibitors (PIs) on cardiac conductivity. We found no significant association between current or recent PI exposure and sudden death or nonhemorrhagic stroke (adjusted rate ratio, 1.22; 95% confidence interval, .95-1.57), whereas cumulative exposure to PIs was associated with an increased risk (adjusted rate ratio, 1.06 per year of exposure; 95% confidence interval, 1.01-1.11).

Abstract

Concerns have arisen about possible effects of protease inhibitors (PIs) on cardiac conductivity. We found no significant association between current or recent PI exposure and sudden death or nonhemorrhagic stroke (adjusted rate ratio, 1.22; 95% confidence interval, .95-1.57), whereas cumulative exposure to PIs was associated with an increased risk (adjusted rate ratio, 1.06 per year of exposure; 95% confidence interval, 1.01-1.11).

Citations

15 citations in Web of Science®
18 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Infectious Diseases
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2012
Deposited On:29 Dec 2012 14:47
Last Modified:05 Apr 2016 16:15
Publisher:Oxford University Press
ISSN:0022-1899
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1093/infdis/jir788
PubMed ID:22223855

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