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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-698

Zipperlen, P; Nairz, K; Rimann, I; Basler, K; Hafen, E; Hengartner, M; Hajnal, A (2005). A universal method for automated gene mapping. Genome Biology, 6(2):R19.

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Abstract

Small insertions or deletions (InDels) constitute a ubiquituous class of sequence polymorphisms found in eukaryotic genomes. Here, we present an automated high-throughput genotyping method that relies on the detection of fragment-length polymorphisms (FLPs) caused by InDels. The protocol utilizes standard sequencers and genotyping software. We have established genome-wide FLP maps for both Caenorhabditis elegans and Drosophila melanogaster that facilitate genetic mapping with a minimum of manual input and at comparatively low cost.

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10 citations in Web of Science®
13 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
DDC:570 Life sciences; biology
Language:English
Date:2005
Deposited On:11 Feb 2008 12:17
Last Modified:27 Nov 2013 19:48
Publisher:BioMed Central
ISSN:1465-6906
Publisher DOI:10.1186/gb-2005-6-2-r19
PubMed ID:15693948

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