Happold, C; Ernemann, U; Roth, P; Wick, W; Weller, M; Schmidt, F (2008). Anticoagulation for radiation-induced neurotoxicity revisited. Journal of Neuro-Oncology, 90(3):357-362.
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No effective treatment for delayed radiation-induced neurotoxicity has been established. Its natural course is highly variable, but spontaneous recovery has been well documented. Here we report our experience with therapeutic anticoagulation in patients with cerebral lesions (n = 3), cranial nerve lesions (n = 1) or myelopathy (n = 4) attributed to irradiation. Two of three patients with cerebral lesions and the patient with cranial nerve lesions showed a minor improvement of clinical symptoms. In contrast, none of the patients with radiation myelopathy improved. No patient suffered hemorrhage or other adverse effects of anticoagulation. Overall, anticoagulation therapy demonstrates only modest activity for delayed radiation-induced neurotoxicity in this small case series.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology|
|Dewey Decimal Classification:||610 Medicine & health|
|Deposited On:||08 Dec 2008 11:14|
|Last Modified:||27 Nov 2013 20:23|
|Additional Information:||The original publication is available at www.springerlink.com|
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