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Metabolic labeling of DNA by purine analogs in vivo


Neef, Anne B; Samain, Florent; Luedtke, Nathan W (2012). Metabolic labeling of DNA by purine analogs in vivo. Chembiochem, 13(12):1750-1753.

Abstract

The 2′-deoxyadenosine analogue “EdA” efficiently labels newly synthesized DNA with alkyne groups in vivo without inhibiting cell cycle progression or embryonic development. This provides the first demonstration that a bio-orthogonal functional group can be metabolically incorporated into DNA through endogenous pathways by addition of a purine analogue to cells.

The 2′-deoxyadenosine analogue “EdA” efficiently labels newly synthesized DNA with alkyne groups in vivo without inhibiting cell cycle progression or embryonic development. This provides the first demonstration that a bio-orthogonal functional group can be metabolically incorporated into DNA through endogenous pathways by addition of a purine analogue to cells.

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13 citations in Web of Science®
13 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Language:English
Date:20 July 2012
Deposited On:05 Feb 2013 12:32
Last Modified:05 Apr 2016 16:23
Publisher:Wiley-VCH Verlag Berlin
ISSN:1439-4227
Publisher DOI:https://doi.org/10.1002/cbic.201200253
Permanent URL: https://doi.org/10.5167/uzh-71535

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