UZH-Logo

Maintenance Infos

Volumetric staging in oropharyngeal cancer patients treated with definitive IMRT


Studer, Gabriela; Glanzmann, Christoph (2013). Volumetric staging in oropharyngeal cancer patients treated with definitive IMRT. Oral Oncology, 49(3):269-276.

Abstract

BACKGROUND: The superiority of volumetric staging (VS) over TNM/TNM-grouping system was previously prospectively tested in our head neck cancer population treated with intensity-modulated radiotherapy (IMRT); gross tumor volume (GTV) was the strongest predictor for disease control. Aim of this work was to specifically assess the prognostic value of VS in oropharyngeal cancer (OC). PATIENTS: Between 04/2002 and 12/2011, 277 consecutive OC patients underwent definitive IMRT. Mean/median follow-up was 33/27months (3-113). Three volumetric cut-offs were used (resulting in 4 GTV subgroups: 1-15cc (14%), 16-70cc (62%), 71-130cc (20%), >130cc (4%)). METHODS: Outcome in the OC subgroup was prospectively assessed with VS and compared with that resulting from TNM and AJCC staging. RESULTS: Primary GTV was most reliably predicting local control (p<0.0001), all other outcome parameters were predicted best by the total GTV (p<0.0001). CONCLUSION: This is -to our knowledge- the first volumetric staging system for OC, and was found to be most reliable in predicting outcome in OC patients treated with IMRT.

Abstract

BACKGROUND: The superiority of volumetric staging (VS) over TNM/TNM-grouping system was previously prospectively tested in our head neck cancer population treated with intensity-modulated radiotherapy (IMRT); gross tumor volume (GTV) was the strongest predictor for disease control. Aim of this work was to specifically assess the prognostic value of VS in oropharyngeal cancer (OC). PATIENTS: Between 04/2002 and 12/2011, 277 consecutive OC patients underwent definitive IMRT. Mean/median follow-up was 33/27months (3-113). Three volumetric cut-offs were used (resulting in 4 GTV subgroups: 1-15cc (14%), 16-70cc (62%), 71-130cc (20%), >130cc (4%)). METHODS: Outcome in the OC subgroup was prospectively assessed with VS and compared with that resulting from TNM and AJCC staging. RESULTS: Primary GTV was most reliably predicting local control (p<0.0001), all other outcome parameters were predicted best by the total GTV (p<0.0001). CONCLUSION: This is -to our knowledge- the first volumetric staging system for OC, and was found to be most reliable in predicting outcome in OC patients treated with IMRT.

Citations

6 citations in Web of Science®
6 citations in Scopus®
Google Scholar™

Altmetrics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Radiation Oncology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2013
Deposited On:25 Mar 2013 08:03
Last Modified:05 Apr 2016 16:26
Publisher:Pergamon
ISSN:1368-8375
Publisher DOI:https://doi.org/10.1016/j.oraloncology.2012.09.014
PubMed ID:23089460

Download

Full text not available from this repository.
View at publisher

TrendTerms

TrendTerms displays relevant terms of the abstract of this publication and related documents on a map. The terms and their relations were extracted from ZORA using word statistics. Their timelines are taken from ZORA as well. The bubble size of a term is proportional to the number of documents where the term occurs. Red, orange, yellow and green colors are used for terms that occur in the current document; red indicates high interlinkedness of a term with other terms, orange, yellow and green decreasing interlinkedness. Blue is used for terms that have a relation with the terms in this document, but occur in other documents.
You can navigate and zoom the map. Mouse-hovering a term displays its timeline, clicking it yields the associated documents.

Author Collaborations