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Effects of exogenous oxytocin on uterine blood flow in puerperal dairy cows: The impact of days after parturition and retained fetal membranes


Magata, F; Hartmann, D; Ishii, M; Miura, R; Takahashi, H; Matsui, M; Kida, K; Miyamoto, A; Bollwein, H (2013). Effects of exogenous oxytocin on uterine blood flow in puerperal dairy cows: The impact of days after parturition and retained fetal membranes. Veterinary Journal, 196(1):76-80.

Abstract

The objective of this study was to examine whether an oxytocin challenge test (OCT), evaluated by measuring the changes in uterine blood flow using transrectal colour Doppler ultrasonography, is a suitable non-invasive method to determine uterine contractility in puerperal dairy cows. The changes in uterine blood flow during uterine contractions induced by oxytocin were evaluated on days 2 and 5 postpartum (pp). Twelve clinically healthy Holstein cows were randomly assigned into two groups: (1) oxytocin group (n=7), 50IU oxytocin injected IM and (2) control group (n=5), 5mL saline injected IM. Blood flow volume (BFV) and pulsatility index (PI) in the uterine arteries were determined before and after injection for 120min on days 2 and 5 pp. BFV declined and PI increased rapidly after oxytocin injection on day 2 (P<0.05), whereas oxytocin on day 5 pp did not cause changes in blood flow parameters. The result confirmed that uterine responsiveness to oxytocin decreases with time postpartum in healthy cows. The same OCT was applied in cows with retained fetal membranes (n=6) on day 2 pp, however uterine blood flow showed no change after oxytocin injection. The results showed that an OCT on day 2 pp may be a useful method for investigating the uterine contractile response to oxytocin (reflected as the decrease of uterine blood flow) and the potential pathophysiology of uterine involution in cows.

The objective of this study was to examine whether an oxytocin challenge test (OCT), evaluated by measuring the changes in uterine blood flow using transrectal colour Doppler ultrasonography, is a suitable non-invasive method to determine uterine contractility in puerperal dairy cows. The changes in uterine blood flow during uterine contractions induced by oxytocin were evaluated on days 2 and 5 postpartum (pp). Twelve clinically healthy Holstein cows were randomly assigned into two groups: (1) oxytocin group (n=7), 50IU oxytocin injected IM and (2) control group (n=5), 5mL saline injected IM. Blood flow volume (BFV) and pulsatility index (PI) in the uterine arteries were determined before and after injection for 120min on days 2 and 5 pp. BFV declined and PI increased rapidly after oxytocin injection on day 2 (P<0.05), whereas oxytocin on day 5 pp did not cause changes in blood flow parameters. The result confirmed that uterine responsiveness to oxytocin decreases with time postpartum in healthy cows. The same OCT was applied in cows with retained fetal membranes (n=6) on day 2 pp, however uterine blood flow showed no change after oxytocin injection. The results showed that an OCT on day 2 pp may be a useful method for investigating the uterine contractile response to oxytocin (reflected as the decrease of uterine blood flow) and the potential pathophysiology of uterine involution in cows.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Veterinary Clinic > Department of Farm Animals
Dewey Decimal Classification:570 Life sciences; biology
630 Agriculture
Language:English
Date:2013
Deposited On:31 Jan 2013 10:23
Last Modified:05 Apr 2016 16:27
Publisher:Elsevier
ISSN:1090-0233
Publisher DOI:https://doi.org/10.1016/j.tvjl.2012.08.010
PubMed ID:22985605
Permanent URL: https://doi.org/10.5167/uzh-72804

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