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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-7325

Donath, M Y; Schumann, D M; Faulenbach, M; Ellingsgaard, H; Perren, A; Ehses, J A (2008). Islet inflammation in type 2 diabetes: from metabolic stress to therapy. Diabetes Care, 31 Sup:S161-S164.

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Decreases in both mass and secretory function of insulin-producing beta-cells contribute to the pathophysiology of type 2 diabetes. The histology of islets from patients with type 2 diabetes displays an inflammatory process characterized by the presence of cytokines, apoptotic cells, immune cell infiltration, amyloid deposits, and eventually fibrosis. This inflammatory process is probably the combined consequence of dyslipidemia, hyperglycemia, and increased circulating adipokines. Therefore, modulation of intra-islet inflammatory mediators, in particular interleukin-1 beta, appears as a promising therapeutic approach.

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Endocrinology and Diabetology
DDC:610 Medicine & health
Deposited On:05 Jan 2009 11:07
Last Modified:27 Nov 2013 19:58
Publisher:American Diabetes Association
Publisher DOI:10.2337/dc08-s243
PubMed ID:18227479
Citations:Web of Science®. Times Cited: 115
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Scopus®. Citation Count: 133

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