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Singer, T; Snozzi, R; Bird, G; Petrovic, P; Silani, G; Heinrichs, M; Dolan, R J (2008). Effects of oxytocin and prosocial behavior on brain responses to directly and vicariously experienced pain. Emotion, 8(6):781-791.

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Abstract

In this study, we tested the validity of 2 popular assumptions about empathy: (a) empathy can be enhanced by oxytocin, a neuropeptide known to be crucial in affiliative behavior, and (b) individual differences in prosocial behavior are positively associated with empathic brain responses. To do so, we measured brain activity in a double-blind placebo-controlled study of 20 male participants either receiving painful stimulation to their own hand (self condition) or observing their female partner receiving painful stimulation to her hand (other condition). Prosocial behavior was measured using a monetary economic interaction game with which participants classified as prosocial (N = 12) or selfish (N = 6), depending on whether they cooperated with another player. Empathy-relevant brain activation (anterior insula) was neither enhanced by oxytocin nor positively associated with prosocial behavior. However, oxytocin reduced amygdala activation when participants received painful stimulation themselves (in the nonsocial condition). Surprisingly, this effect was driven by "selfish" participants. The results suggest that selfish individuals may not be as rational and unemotional as usually suggested, their actions being determined by their feeling anxious rather than by reason.

Item Type:Journal Article, refereed, original work
Communities & Collections:06 Faculty of Arts > Institute of Psychology
DDC:150 Psychology
Language:English
Date:2008
Deposited On:12 Jan 2009 12:47
Last Modified:27 Nov 2013 22:23
Publisher:American Psychological Association
ISSN:1528-3542
Publisher DOI:10.1037/a0014195
PubMed ID:19102589
Citations:Web of Science®. Times Cited: 72
Google Scholar™
Scopus®. Citation Count: 73

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