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Berset, T; Froehli Hoier, E; Battu, G; Canevascini, S; Hajnal, A (2001). Notch inhibition of RAS signaling through MAP kinase phosphatase LIP-1 during C. elegans vulval development. Science, 291(5506):1055-1058.

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During Caenorhabditis elegans vulval development, a signal from the anchor cell stimulates the RTK/RAS/MAPK (receptor tyrosine kinase/RAS/mitogen-activated protein kinase) signaling pathway in the closest vulval precursor cell P6.p to induce the primary fate. A lateral signal from P6.p then activates the Notch signaling pathway in the neighboring cells P5.p and P7.p to prevent them from adopting the primary fate and to specify the secondary fate. The MAP kinase phosphatase LIP-1 mediates this lateral inhibition of the primary fate. LIN-12/NOTCH up-regulates lip-1 transcription in P5.p and P7.p where LIP-1 inactivates the MAP kinase to inhibit primary fate specification. LIP-1 thus links the two signaling pathways to generate a pattern.

Item Type:Journal Article, refereed
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
DDC:570 Life sciences; biology
Date:9 February 2001
Deposited On:11 Feb 2008 12:17
Last Modified:27 Nov 2013 18:49
Publisher:American Association for the Advancement of Science (AAAS)
Publisher DOI:10.1126/science.1055642
PubMed ID:11161219
Citations:Web of Science®. Times Cited: 160
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Scopus®. Citation Count: 166

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