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Long-term survival and interruption of HAART in HIV-related pulmonary hypertension


Zinkernagel, A S; von Overbeck, J; Opravil, M; Jenni, R; Speich, R; Mueller, N J (2005). Long-term survival and interruption of HAART in HIV-related pulmonary hypertension. European Journal of Clinical Microbiology & Infectious Diseases, 24(2):153-155.

Abstract

Reported here is a case of a patient with pulmonary arterial hypertension related to HIV (PAHRH) in which lipodystrophy necessitated interruption of highly active antiretroviral therapy (HAART) and long-term survival was the outcome. Although previous studies have suggested antiretroviral therapy may benefit patients with this rare complication of HIV infection, no worsening of PAHRH was observed when HAART was interrupted. Clinical and echocardiographic parameters remained stable during 7 months of follow up. In cases in which HAART is associated with relevant toxicity, interruption of HAART in patients with PAHRH can be considered, but should be used only if no alternatives are available. Close follow-up is warranted.

Abstract

Reported here is a case of a patient with pulmonary arterial hypertension related to HIV (PAHRH) in which lipodystrophy necessitated interruption of highly active antiretroviral therapy (HAART) and long-term survival was the outcome. Although previous studies have suggested antiretroviral therapy may benefit patients with this rare complication of HIV infection, no worsening of PAHRH was observed when HAART was interrupted. Clinical and echocardiographic parameters remained stable during 7 months of follow up. In cases in which HAART is associated with relevant toxicity, interruption of HAART in patients with PAHRH can be considered, but should be used only if no alternatives are available. Close follow-up is warranted.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic and Policlinic for Internal Medicine
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2005
Deposited On:17 Apr 2013 11:08
Last Modified:05 Apr 2016 16:36
Publisher:Springer
ISSN:0934-9723
Publisher DOI:https://doi.org/10.1007/s10096-005-1289-7
PubMed ID:15711784

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