UZH-Logo

In Drosophila, female gonadal cells repress male-specific gene expression in XX germ cells.


Heller, A; Steinmann-Zwicky, M (1998). In Drosophila, female gonadal cells repress male-specific gene expression in XX germ cells. Mechanisms of Development, 73(2):203-209.

Abstract

In Drosophila, the sex of XX germ cells is determined by somatic signals. Whether sex-specific genes, however, are activated or repressed by somatic signals is not known. We have used mgm1, a germline-marker which is specifically expressed in male germ cells to analyze sex-specific gene expression of embryonic germ cells. We found that XX and XY germ cells that do not contact gonadal tissue can express mgm1. In contrast, XX germ cells that were associated with female somatic gonadal cells never expressed mgm1. Our results suggest that XX germ cells express male-specific genes, unless these genes are repressed by feminizing short range signals produced by the somatic cells of the prospective ovary.

In Drosophila, the sex of XX germ cells is determined by somatic signals. Whether sex-specific genes, however, are activated or repressed by somatic signals is not known. We have used mgm1, a germline-marker which is specifically expressed in male germ cells to analyze sex-specific gene expression of embryonic germ cells. We found that XX and XY germ cells that do not contact gonadal tissue can express mgm1. In contrast, XX germ cells that were associated with female somatic gonadal cells never expressed mgm1. Our results suggest that XX germ cells express male-specific genes, unless these genes are repressed by feminizing short range signals produced by the somatic cells of the prospective ovary.

Citations

10 citations in Web of Science®
9 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

52 downloads since deposited on 11 Feb 2008
25 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:1 May 1998
Deposited On:11 Feb 2008 12:17
Last Modified:05 Apr 2016 12:15
Publisher:Elsevier
ISSN:0925-4773
Publisher DOI:10.1016/S0925-4773(98)00053-7
PubMed ID:9622631
Permanent URL: http://doi.org/10.5167/uzh-752

Download

[img]
Preview
Filetype: PDF
Size: 509kB
View at publisher

TrendTerms

TrendTerms displays relevant terms of the abstract of this publication and related documents on a map. The terms and their relations were extracted from ZORA using word statistics. Their timelines are taken from ZORA as well. The bubble size of a term is proportional to the number of documents where the term occurs. Red, orange, yellow and green colors are used for terms that occur in the current document; red indicates high interlinkedness of a term with other terms, orange, yellow and green decreasing interlinkedness. Blue is used for terms that have a relation with the terms in this document, but occur in other documents.
You can navigate and zoom the map. Mouse-hovering a term displays its timeline, clicking it yields the associated documents.

Author Collaborations