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Castleman's disease and arterial thrombosis: result of excessively elevated interleukin-6 plasma level?


Schumacher, Anette; Jacomella, Vincenzo; Stüssi, Georg; Amann-Vesti, Beatrice; Corti, Natascia; Marc Husmann, And (2012). Castleman's disease and arterial thrombosis: result of excessively elevated interleukin-6 plasma level? Vasa, 41(2):145-148.

Abstract

Morbus Castleman is a benign non-clonal lymphoproliverative disorder. Immunomodulatory and antiproliferative drugs are used to treat this plasma cell disorder. We report the case of a 46-year old female patient with multicentric Castleman's disease and limb ischemia. Thrombotic occlusions of the popliteal and tibioperoneal arteries were treated by percutaneous thrombus aspiration. We discuss the role of increased interleukin-6 plasma levels during therapy with Tocilizumab, an antibody to interleukin-6 receptor, as a potential cause for arterial thrombosis.

Abstract

Morbus Castleman is a benign non-clonal lymphoproliverative disorder. Immunomodulatory and antiproliferative drugs are used to treat this plasma cell disorder. We report the case of a 46-year old female patient with multicentric Castleman's disease and limb ischemia. Thrombotic occlusions of the popliteal and tibioperoneal arteries were treated by percutaneous thrombus aspiration. We discuss the role of increased interleukin-6 plasma levels during therapy with Tocilizumab, an antibody to interleukin-6 receptor, as a potential cause for arterial thrombosis.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Clinical Pharmacology and Toxicology
Dewey Decimal Classification:610 Medicine & health
Language:German
Date:2012
Deposited On:07 Mar 2013 10:15
Last Modified:05 Apr 2016 16:37
Publisher:Hans Huber
ISSN:0301-1526
Publisher DOI:https://doi.org/10.1024/0301-1526/a000178
PubMed ID:22403134

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