Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive 

Bienz, M; Kubli, E (1981). Wild-type tRNATyrG reads the TMV RNA stop codon, but Q base-modified tRNATyrQ does not. Nature, 294(5837):188-190.

Full text not available from this repository.

Abstract

Although protein synthesis usually terminates when a stop codon is reached along the messenger RNA sequence, there are examples, mainly in viruses, of the stop codon being suppressed by a tRNA species. A strong candidate for this phenomenon occurs in tobacco mosaic virus (TMV) in the form of two proteins (110K and 160K, of molecular weights 110,000 and 160,000, respectively)1, sharing an N-terminus sequence, which are translated in vitro from a purified species of viral RNA. We have investigated the identity of the tRNA responsible for production of the 160K protein and show here that it is one of the tyrosine tRNAs. Another tyrosine tRNA, in which the first base of the anticodon is highly modified, does not act as a suppressor, indicating the possible regulatory function of such modifications.

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Zoology (former)
DDC:570 Life sciences; biology
590 Animals (Zoology)
Language:English
Date:1981
Deposited On:11 Feb 2008 12:18
Last Modified:27 Nov 2013 23:39
Publisher:Nature Publishing Group
ISSN:0028-0836
Publisher DOI:10.1038/294188a0
Citations:Web of Science®. Times Cited: 123
Google Scholar™

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page