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Towards a comprehensive catalog of Zebrafish behavior 1.0 and beyond


Kalueff, Allan V; Gebhardt, Michael; Stewart, Adam Michael (2013). Towards a comprehensive catalog of Zebrafish behavior 1.0 and beyond. Zebrafish, 10(1):70-86.

Abstract

Zebrafish (Danio rerio) are rapidly gaining popularity in translational neuroscience and behavioral research. Physiological similarity to mammals, ease of genetic manipulations, sensitivity to pharmacological and genetic factors, robust behavior, low cost, and potential for high-throughput screening contribute to the growing utility of zebrafish models in this field. Understanding zebrafish behavioral phenotypes provides important insights into neural pathways, physiological biomarkers, and genetic underpinnings of normal and pathological brain function. Novel zebrafish paradigms continue to appear with an encouraging pace, thus necessitating a consistent terminology and improved understanding of the behavioral repertoire. What can zebrafish ‘do’, and how does their altered brain function translate into behavioral actions? To help address these questions, we have developed a detailed catalog of zebrafish behaviors (Zebrafish Behavior Catalog, ZBC) that covers both larval and adult models. Representing a beginning of creating a more comprehensive ethogram of zebrafish behavior, this effort will improve interpretation of published findings, foster cross-species behavioral modeling, and encourage new groups to apply zebrafish neurobehavioral paradigms in their research. In addition, this glossary creates a framework for developing a
zebrafish neurobehavioral ontology, ultimately to become part of a unified animal neurobehavioral ontology, which
collectively will contribute to better integration of biological data within and across species.

Abstract

Zebrafish (Danio rerio) are rapidly gaining popularity in translational neuroscience and behavioral research. Physiological similarity to mammals, ease of genetic manipulations, sensitivity to pharmacological and genetic factors, robust behavior, low cost, and potential for high-throughput screening contribute to the growing utility of zebrafish models in this field. Understanding zebrafish behavioral phenotypes provides important insights into neural pathways, physiological biomarkers, and genetic underpinnings of normal and pathological brain function. Novel zebrafish paradigms continue to appear with an encouraging pace, thus necessitating a consistent terminology and improved understanding of the behavioral repertoire. What can zebrafish ‘do’, and how does their altered brain function translate into behavioral actions? To help address these questions, we have developed a detailed catalog of zebrafish behaviors (Zebrafish Behavior Catalog, ZBC) that covers both larval and adult models. Representing a beginning of creating a more comprehensive ethogram of zebrafish behavior, this effort will improve interpretation of published findings, foster cross-species behavioral modeling, and encourage new groups to apply zebrafish neurobehavioral paradigms in their research. In addition, this glossary creates a framework for developing a
zebrafish neurobehavioral ontology, ultimately to become part of a unified animal neurobehavioral ontology, which
collectively will contribute to better integration of biological data within and across species.

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107 citations in Web of Science®
112 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:1 March 2013
Deposited On:24 Apr 2013 11:06
Last Modified:05 Apr 2016 16:45
Publisher:Mary Ann Liebert
ISSN:1545-8547
Additional Information:This is a copy of an article published in Zebrafish © 2013 Mary Ann Liebert, Inc.; Zebrafish is available online at: http://www.liebertonline.com.
Publisher DOI:https://doi.org/10.1089/zeb.2012.0861

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