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A new hybrid Bayesian-variational particle filter with application to mitotic cell tracking


Delgado-Gonzalo, Ricard; Chenouard, Nicolas; Unser, Michael (2011). A new hybrid Bayesian-variational particle filter with application to mitotic cell tracking. In: International Symposium on Biomedical Imaging, Chicago, IL, 30 March 2011 - 2 April 2011.

Abstract

Tracking algorithms are traditionally based on either a variational approach or a Bayesian one. In the variational case, a cost function is established between two consecutive frames and minimized by standard optimization algorithms. In the Bayesian case, a stochastic motion model is used to maintain temporal consistency. Among the Bayesian methods we focus on the particle filter, which is especially suited for handling multimodal distributions. In this paper, we present a novel approach to fuse both methodologies in a single tracker where the importance sampling of the particle filter is given implicitly by the optimization algorithm of the variational method. Our technique is capable of outlying nuclei and tracking the lineage of biological cells using different motion models for mitotic and non-mitotic stages of the life of a cell. We validate its ability to track the lineage of HeLa cells in fluorescence microscopy.

Tracking algorithms are traditionally based on either a variational approach or a Bayesian one. In the variational case, a cost function is established between two consecutive frames and minimized by standard optimization algorithms. In the Bayesian case, a stochastic motion model is used to maintain temporal consistency. Among the Bayesian methods we focus on the particle filter, which is especially suited for handling multimodal distributions. In this paper, we present a novel approach to fuse both methodologies in a single tracker where the importance sampling of the particle filter is given implicitly by the optimization algorithm of the variational method. Our technique is capable of outlying nuclei and tracking the lineage of biological cells using different motion models for mitotic and non-mitotic stages of the life of a cell. We validate its ability to track the lineage of HeLa cells in fluorescence microscopy.

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5 citations in Web of Science®
6 citations in Scopus®
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Additional indexing

Item Type:Conference or Workshop Item (Paper), refereed, original work
Communities & Collections:Special Collections > SystemsX.ch
Special Collections > SystemsX.ch > Research, Technology and Development Projects > DynamiX
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Event End Date:2 April 2011
Deposited On:23 Jun 2013 15:50
Last Modified:05 Apr 2016 16:49
Publisher DOI:https://doi.org/10.1109/ISBI.2011.5872784
Permanent URL: https://doi.org/10.5167/uzh-78717

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