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The global burden of congenital toxoplasmosis: a systematic review


Torgerson, Paul R; Mastroiacovo, P (2013). The global burden of congenital toxoplasmosis: a systematic review. Bulletin of the World Health Organisation, 91:501-508.

Abstract

Objective To estimate the global burden of congenital toxoplasmosis (CT), which results from infection of pregnant women with Toxoplasma gondii.
Methods The authors systematically searched 9 major databases for published and unpublished sources and established direct contact with the authors of source materials. Searches were country-specific. To be included, studies had to report on the incidence of CT, on positivity to Toxoplasma-specific IgM in infants and pregnant women (including seroconversion results) or on positivity to Toxoplasma-specific IgG in the general population. Various modelling techniques were used, depending on the country-specific data available, to estimate the CT incidence and burden in each country. These data were then synthesized into an estimate of the global incidence of CT and of the global burden of CT in disability-adjusted life years (DALYs).
Findings The global annual incidence of congenital toxoplasmosis was estimated to be 190 100 cases (95% credible interval, CI: 179 300–206 300). This was equivalent to a burden of 1.20 million DALYs (95% CI: 0.76–1.90). High burdens were seen in South America and in some Middle Eastern and low-income countries.
Conclusion Congenital toxoplasmosis poses a substantial burden of poor health globally. Toxoplasmosis should be included in future updates of the global burden of disease and the corresponding data should be used to support public health interventions to reduce disease burden.
a Section

Abstract

Objective To estimate the global burden of congenital toxoplasmosis (CT), which results from infection of pregnant women with Toxoplasma gondii.
Methods The authors systematically searched 9 major databases for published and unpublished sources and established direct contact with the authors of source materials. Searches were country-specific. To be included, studies had to report on the incidence of CT, on positivity to Toxoplasma-specific IgM in infants and pregnant women (including seroconversion results) or on positivity to Toxoplasma-specific IgG in the general population. Various modelling techniques were used, depending on the country-specific data available, to estimate the CT incidence and burden in each country. These data were then synthesized into an estimate of the global incidence of CT and of the global burden of CT in disability-adjusted life years (DALYs).
Findings The global annual incidence of congenital toxoplasmosis was estimated to be 190 100 cases (95% credible interval, CI: 179 300–206 300). This was equivalent to a burden of 1.20 million DALYs (95% CI: 0.76–1.90). High burdens were seen in South America and in some Middle Eastern and low-income countries.
Conclusion Congenital toxoplasmosis poses a substantial burden of poor health globally. Toxoplasmosis should be included in future updates of the global burden of disease and the corresponding data should be used to support public health interventions to reduce disease burden.
a Section

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64 citations in Web of Science®
52 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Chair in Veterinary Epidemiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:1 July 2013
Deposited On:04 Jul 2013 07:25
Last Modified:05 Apr 2016 16:50
Publisher:World Health Organisation
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.2471/BLT.12.111732
Official URL:http://www.who.int/bulletin/volumes/91/7/12-111732-ab/en/index.html

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