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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-7918

Camici, G G; Cosentino, C; Tanner, F C; Lüscher, T F (2008). The role of p66Shc deletion in age-associated arterial dysfunction and disease states. Journal of Applied Physiology, 105(5):1628-1631.

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Abstract

Accumulation of oxidative stress with age is hypothesized to be the primary causative mediator of age-associated diseases. Among different tissues, aging vessels are known to accumulate oxidative damage and undergo functional impairment. Oxidative stress affects the availability and/or balance of key regulators of vascular homeostasis and favors the development of cardiovascular disease. Reactive oxygen species are generated by different intracellular molecular pathways principally located in the cytoplasm and in the mitochondria. The mitochondrial enzyme p66Shc is an adaptor protein and plays an important role as a redox enzyme implicated in mitochondrial eactive oxygen species generation and translation of oxidative signals into apoptosis. Mice lacking p66Shc–/– gene display reduced production of intracellular oxidants and a 30% prolonged life span. For this reasons, a series of studies conceived to elucidate the function of p66Shc and its possible implication in age-associated cardiovascular diseases have been carried out. Indeed, p66Shc–/– mice have been shown to be protected from age-dependent endothelial dysfunction as well as age-related risk factors such as diabetes and hypercholesterolemia. This review focuses on delineating the role of the p66Shc adaptor protein and its potential implication in the pathophysiology of aging and age-related cardiovascular disease.

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Center for Integrative Human Physiology
04 Faculty of Medicine > University Hospital Zurich > Clinic for Cardiology
04 Faculty of Medicine > Institute of Physiology
07 Faculty of Science > Institute of Physiology
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:22 November 2008
Deposited On:23 Dec 2008 12:01
Last Modified:27 Nov 2013 21:48
Publisher:American Physiological Society
ISSN:0161-7567
Publisher DOI:10.1152/japplphysiol.90579.2008
PubMed ID:18772327
Citations:Web of Science®. Times Cited: 24
Google Scholar™
Scopus®. Citation Count: 21

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