Quick Search:

uzh logo
Browse by:

Zurich Open Repository and Archive

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-7922

Breitenstein, A; Stämpfli, S F; Camici, G G; Akhmedov, H R; Ha, H R; Follath, F; Bogdanova, A; Lüscher, T F; Tanner, F C (2008). Amiodarone inhibits arterial thrombus formation and tissue factor translation. Arteriosclerosis Thrombosis and Vascular Biology, 28(12):2231-2238.

[img]Accepted Version
PDF - Registered users only
View at publisher


BACKGROUND: In patients with coronary artery disease and reduced ejection fraction, amiodarone reduces mortality by decreasing sudden death. Because the latter may be triggered by coronary artery thrombosis as much as ventricular arrhythmias, amiodarone might interfere with tissue factor (TF) expression and thrombus formation. METHODS AND RESULTS: Clinically relevant plasma concentrations of amiodarone reduced TF activity and impaired carotid artery thrombus formation in a mouse photochemical injury model in vivo. PTT, aPTT, and tail bleeding time were not affected; platelet number was slightly decreased. In human endothelial and vascular smooth muscle cells, amiodarone inhibited tumor necrosis factor (TNF)-alpha and thrombin-induced TF expression as well as surface activity. Amiodarone lacking iodine and the main metabolite of amiodarone, N-monodesethylamiodarone, inhibited TF expression. Amiodarone did not affect mitogen-activated protein kinase activation, TF mRNA expression, and TF protein degradation. Metabolic labeling confirmed that amiodarone inhibited TF protein translation. CONCLUSIONS: Amiodarone impairs thrombus formation in vivo; in line with this, it inhibits TF protein expression and surface activity in human vascular cells. These pleiotropic actions occur within the range of amiodarone concentrations measured in patients, and thus may account at least in part for its beneficial effects in patients with coronary artery disease.


14 citations in Web of Science®
13 citations in Scopus®
Google Scholar™



26 downloads since deposited on 16 Dec 2008
4 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Veterinary Physiology
04 Faculty of Medicine > Center for Integrative Human Physiology
04 Faculty of Medicine > University Hospital Zurich > Clinic for Cardiology
04 Faculty of Medicine > University Hospital Zurich > Clinic for Cardiovascular Surgery
04 Faculty of Medicine > Institute of Physiology
07 Faculty of Science > Institute of Physiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Date:December 2008
Deposited On:16 Dec 2008 12:02
Last Modified:05 Apr 2016 12:42
Publisher:Lippincott Wiliams & Wilkins
Funders:Swiss National Science Foundation, Bonizzi-Theler Foundation, Velux Foundation, Wolfermann Nägeli Foundation, MERCATOR Foundation, Swiss Heart Foundation
Additional Information:This is a non-final version of an article published in final form in http://atvb.ahajournals.org/cgi/content/abstract/28/12/2231
Publisher DOI:10.1161/ATVBAHA.108.171272
PubMed ID:18974383

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page